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The impact of the duration of an untreated episode on improvement of depression and somatic symptoms

PURPOSE: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. METHODS: In this open-labe...

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Autores principales: Hung, Ching-I, Yu, Nan-Wen, Liu, Chia-Yih, Wu, Kuan-Yi, Yang, Ching-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556250/
https://www.ncbi.nlm.nih.gov/pubmed/26346571
http://dx.doi.org/10.2147/NDT.S89498
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author Hung, Ching-I
Yu, Nan-Wen
Liu, Chia-Yih
Wu, Kuan-Yi
Yang, Ching-Hui
author_facet Hung, Ching-I
Yu, Nan-Wen
Liu, Chia-Yih
Wu, Kuan-Yi
Yang, Ching-Hui
author_sort Hung, Ching-I
collection PubMed
description PURPOSE: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. METHODS: In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. RESULTS: Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. CONCLUSION: A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms.
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spelling pubmed-45562502015-09-04 The impact of the duration of an untreated episode on improvement of depression and somatic symptoms Hung, Ching-I Yu, Nan-Wen Liu, Chia-Yih Wu, Kuan-Yi Yang, Ching-Hui Neuropsychiatr Dis Treat Original Research PURPOSE: The aim of this study was to investigate the impact of the duration of an untreated episode (DUE) on the improvement of depression and somatic symptoms among patients with major depressive disorder (MDD), after the patients had received 4 weeks of pharmacotherapy. METHODS: In this open-label study, there were 155 participants with MDD who were treated daily with 75 mg of venlafaxine for 4 weeks. DUE was defined as the interval between the onset of the index major depressive episode and the start of pharmacotherapy. The Depression and Somatic Symptoms Scale (DSSS), composed of the depression subscale (DS) and the somatic subscale (SS), was used. The SS included the pain subscale (PS) and the nonpain somatic subscale (NPSS). Multiple linear regressions were used to test the impacts of DUE on the improvement percentages (IPs) of depression and somatic symptoms. RESULTS: Eighty-five subjects completed the 4-week treatment. The IPs of the DS, SS, and NPSS were significantly negatively correlated with DUE. A shorter DUE was related to higher IPs. DUE was an independent factor, predicting the IPs of the DS, SS, and NPSS. DUE <1 month was the most powerful time-point to predict the IPs of the DS, SS, and NPSS. However, DUE was unable to predict the IP of the PS at all time-points. CONCLUSION: A shorter DUE might be one of the factors related to greater improvement of depression and somatic symptoms. DUE should be considered as an important factor when investigating the prognosis of depression and somatic symptoms. Dove Medical Press 2015-08-27 /pmc/articles/PMC4556250/ /pubmed/26346571 http://dx.doi.org/10.2147/NDT.S89498 Text en © 2015 Hung et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Hung, Ching-I
Yu, Nan-Wen
Liu, Chia-Yih
Wu, Kuan-Yi
Yang, Ching-Hui
The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_full The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_fullStr The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_full_unstemmed The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_short The impact of the duration of an untreated episode on improvement of depression and somatic symptoms
title_sort impact of the duration of an untreated episode on improvement of depression and somatic symptoms
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556250/
https://www.ncbi.nlm.nih.gov/pubmed/26346571
http://dx.doi.org/10.2147/NDT.S89498
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