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Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study

INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T...

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Autores principales: Shao, Rui, Li, Chun-Sheng, Fang, Yingying, Zhao, Lianxing, Hang, Chenchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556404/
https://www.ncbi.nlm.nih.gov/pubmed/26329820
http://dx.doi.org/10.1186/s13054-015-1024-4
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author Shao, Rui
Li, Chun-Sheng
Fang, Yingying
Zhao, Lianxing
Hang, Chenchen
author_facet Shao, Rui
Li, Chun-Sheng
Fang, Yingying
Zhao, Lianxing
Hang, Chenchen
author_sort Shao, Rui
collection PubMed
description INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early stage of sepsis with the severity and mortality of septic patients in the emergency department (ED). METHODS: 336 consecutive patients were included in this study. BTLA expression on CD4(+) T cells was measured by flow cytometry within 24h of ED admission. RESULTS: Our results showed that the percentage of BTLA(+)/CD4(+) T cells was high expression in healthy volunteers and it was statistically reduced in severe sepsis and septic shock compared with healthy controls(all P<0.01). The area under the receiver operating characteristic (AUC) curves of BTLA expression on CD4(+) T cells was slightly lower than that of procalcitonin (PCT) and Mortality in Emergency Department Sepsis (MEDS) score. The percentage of BTLA(+)/CD4(+)T cells was lower in non-survivors than in survivors (P<0.01), and similar results were obtained when expressed as mean of fluorescence intensities (MFI) (P<0.01). Adjusted logistic regression analysis suggested that the percentage of BTLA(+)/CD4(+) T cells was associated with 28-day mortality in septic patients (odds ratio (OR) = 0.394). CONCLUSION: Our study shows that the percentage of BTLA(+)/CD4(+) T cells was high in healthy volunteers. Furthermore, lower percentage of BTLA(+)/CD4(+) T cells during the early stage of sepsis is associated with the severity and the mortality of septic patients.
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spelling pubmed-45564042015-09-02 Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study Shao, Rui Li, Chun-Sheng Fang, Yingying Zhao, Lianxing Hang, Chenchen Crit Care Research INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early stage of sepsis with the severity and mortality of septic patients in the emergency department (ED). METHODS: 336 consecutive patients were included in this study. BTLA expression on CD4(+) T cells was measured by flow cytometry within 24h of ED admission. RESULTS: Our results showed that the percentage of BTLA(+)/CD4(+) T cells was high expression in healthy volunteers and it was statistically reduced in severe sepsis and septic shock compared with healthy controls(all P<0.01). The area under the receiver operating characteristic (AUC) curves of BTLA expression on CD4(+) T cells was slightly lower than that of procalcitonin (PCT) and Mortality in Emergency Department Sepsis (MEDS) score. The percentage of BTLA(+)/CD4(+)T cells was lower in non-survivors than in survivors (P<0.01), and similar results were obtained when expressed as mean of fluorescence intensities (MFI) (P<0.01). Adjusted logistic regression analysis suggested that the percentage of BTLA(+)/CD4(+) T cells was associated with 28-day mortality in septic patients (odds ratio (OR) = 0.394). CONCLUSION: Our study shows that the percentage of BTLA(+)/CD4(+) T cells was high in healthy volunteers. Furthermore, lower percentage of BTLA(+)/CD4(+) T cells during the early stage of sepsis is associated with the severity and the mortality of septic patients. BioMed Central 2015-08-28 2015 /pmc/articles/PMC4556404/ /pubmed/26329820 http://dx.doi.org/10.1186/s13054-015-1024-4 Text en © Shao et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shao, Rui
Li, Chun-Sheng
Fang, Yingying
Zhao, Lianxing
Hang, Chenchen
Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title_full Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title_fullStr Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title_full_unstemmed Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title_short Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
title_sort low b and t lymphocyte attenuator expression on cd4(+) t cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556404/
https://www.ncbi.nlm.nih.gov/pubmed/26329820
http://dx.doi.org/10.1186/s13054-015-1024-4
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