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Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study
INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556404/ https://www.ncbi.nlm.nih.gov/pubmed/26329820 http://dx.doi.org/10.1186/s13054-015-1024-4 |
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author | Shao, Rui Li, Chun-Sheng Fang, Yingying Zhao, Lianxing Hang, Chenchen |
author_facet | Shao, Rui Li, Chun-Sheng Fang, Yingying Zhao, Lianxing Hang, Chenchen |
author_sort | Shao, Rui |
collection | PubMed |
description | INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early stage of sepsis with the severity and mortality of septic patients in the emergency department (ED). METHODS: 336 consecutive patients were included in this study. BTLA expression on CD4(+) T cells was measured by flow cytometry within 24h of ED admission. RESULTS: Our results showed that the percentage of BTLA(+)/CD4(+) T cells was high expression in healthy volunteers and it was statistically reduced in severe sepsis and septic shock compared with healthy controls(all P<0.01). The area under the receiver operating characteristic (AUC) curves of BTLA expression on CD4(+) T cells was slightly lower than that of procalcitonin (PCT) and Mortality in Emergency Department Sepsis (MEDS) score. The percentage of BTLA(+)/CD4(+)T cells was lower in non-survivors than in survivors (P<0.01), and similar results were obtained when expressed as mean of fluorescence intensities (MFI) (P<0.01). Adjusted logistic regression analysis suggested that the percentage of BTLA(+)/CD4(+) T cells was associated with 28-day mortality in septic patients (odds ratio (OR) = 0.394). CONCLUSION: Our study shows that the percentage of BTLA(+)/CD4(+) T cells was high in healthy volunteers. Furthermore, lower percentage of BTLA(+)/CD4(+) T cells during the early stage of sepsis is associated with the severity and the mortality of septic patients. |
format | Online Article Text |
id | pubmed-4556404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45564042015-09-02 Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study Shao, Rui Li, Chun-Sheng Fang, Yingying Zhao, Lianxing Hang, Chenchen Crit Care Research INTRODUCTION: B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, whose primary role in CD4(+) T cell is thought to inhibit cytokine production. We explore BTLA expression on CD4(+) T cells in healthy controls and septic patients, and assess the correlation of BTLA expression on CD4(+) T cells in the early stage of sepsis with the severity and mortality of septic patients in the emergency department (ED). METHODS: 336 consecutive patients were included in this study. BTLA expression on CD4(+) T cells was measured by flow cytometry within 24h of ED admission. RESULTS: Our results showed that the percentage of BTLA(+)/CD4(+) T cells was high expression in healthy volunteers and it was statistically reduced in severe sepsis and septic shock compared with healthy controls(all P<0.01). The area under the receiver operating characteristic (AUC) curves of BTLA expression on CD4(+) T cells was slightly lower than that of procalcitonin (PCT) and Mortality in Emergency Department Sepsis (MEDS) score. The percentage of BTLA(+)/CD4(+)T cells was lower in non-survivors than in survivors (P<0.01), and similar results were obtained when expressed as mean of fluorescence intensities (MFI) (P<0.01). Adjusted logistic regression analysis suggested that the percentage of BTLA(+)/CD4(+) T cells was associated with 28-day mortality in septic patients (odds ratio (OR) = 0.394). CONCLUSION: Our study shows that the percentage of BTLA(+)/CD4(+) T cells was high in healthy volunteers. Furthermore, lower percentage of BTLA(+)/CD4(+) T cells during the early stage of sepsis is associated with the severity and the mortality of septic patients. BioMed Central 2015-08-28 2015 /pmc/articles/PMC4556404/ /pubmed/26329820 http://dx.doi.org/10.1186/s13054-015-1024-4 Text en © Shao et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Shao, Rui Li, Chun-Sheng Fang, Yingying Zhao, Lianxing Hang, Chenchen Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title | Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title_full | Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title_fullStr | Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title_full_unstemmed | Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title_short | Low B and T lymphocyte attenuator expression on CD4(+) T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
title_sort | low b and t lymphocyte attenuator expression on cd4(+) t cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556404/ https://www.ncbi.nlm.nih.gov/pubmed/26329820 http://dx.doi.org/10.1186/s13054-015-1024-4 |
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