Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm

An important goal in molecular biology is to understand functional changes upon single-point mutations in proteins. Doing so through a detailed characterization of structure spaces and underlying energy landscapes is desirable but continues to challenge methods based on Molecular Dynamics. In this p...

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Detalles Bibliográficos
Autores principales: Clausen, Rudy, Ma, Buyong, Nussinov, Ruth, Shehu, Amarda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556523/
https://www.ncbi.nlm.nih.gov/pubmed/26325505
http://dx.doi.org/10.1371/journal.pcbi.1004470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556523/
https://www.ncbi.nlm.nih.gov/pubmed/26325505
http://dx.doi.org/10.1371/journal.pcbi.1004470

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