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Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression

BACKGROUND: Recent systematic reviews of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS) revealed a decrease in placebo annualized relapse rates (ARR) over the past two decades. Furthermore, regression to the mean effects were observed in ARR and MRI lesion counts. It is un...

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Detalles Bibliográficos
Autores principales:	Röver, Christian, Nicholas, Richard, Straube, Sebastian, Friede, Tim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556534/ https://www.ncbi.nlm.nih.gov/pubmed/26327532 http://dx.doi.org/10.1371/journal.pone.0137052

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