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Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery

Acute Kidney Injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Since heart fatty acid binding protein (H-FABP) is a myocardial protein that detects cardiac injury, we sought to determine if plasma H-FABP was associated with AKI in the TRIBE-AKI cohort...

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Autores principales: Schaub, Jennifer A., Garg, Amit X., Coca, Steven G., Testani, Jeffrey M., Shlipak, Michael G., Eikelboom, John, Kavsak, Peter, McArthur, Eric, Shortt, Colleen, Whitlock, Richard, Parikh, Chirag R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556547/
https://www.ncbi.nlm.nih.gov/pubmed/25830762
http://dx.doi.org/10.1038/ki.2015.104
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author Schaub, Jennifer A.
Garg, Amit X.
Coca, Steven G.
Testani, Jeffrey M.
Shlipak, Michael G.
Eikelboom, John
Kavsak, Peter
McArthur, Eric
Shortt, Colleen
Whitlock, Richard
Parikh, Chirag R.
author_facet Schaub, Jennifer A.
Garg, Amit X.
Coca, Steven G.
Testani, Jeffrey M.
Shlipak, Michael G.
Eikelboom, John
Kavsak, Peter
McArthur, Eric
Shortt, Colleen
Whitlock, Richard
Parikh, Chirag R.
author_sort Schaub, Jennifer A.
collection PubMed
description Acute Kidney Injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Since heart fatty acid binding protein (H-FABP) is a myocardial protein that detects cardiac injury, we sought to determine if plasma H-FABP was associated with AKI in the TRIBE-AKI cohort; a multi-center cohort of 1219 patients at high risk for AKI who underwent cardiac surgery. The primary outcomes of interest were any AKI (Acute Kidney Injury Network (AKIN) stage 1 or higher) and severe AKI (AKIN stage 2 or higher). The secondary outcome was long-term mortality after discharge. Patients who developed AKI had higher levels of H-FABP pre- and post-operatively than patients who did not have AKI. In analyses adjusted for known AKI risk factors, first post-operative log(H-FABP) was associated with severe AKI (adjusted OR 5.39 [95% CI, 2.87-10.11] per unit increase), while pre-operative log(H-FABP) was associated with any AKI (2.07 [1.48-2.89]) and mortality (1.67 [1.17-2.37]). These relationships persisted after adjustment for change in serum creatinine (for first postoperative log(H-FABP)) and biomarkers of cardiac and kidney injury, including brain natriuretic peptide, cardiac troponin-I, interleukin-18, liver fatty acid binding protein, kidney injury molecule-1, and neutrophil gelatinase associated lipocalin. Thus, peri-operative plasma H-FABP levels may be used for risk-stratification of AKI and mortality following cardiac surgery.
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spelling pubmed-45565472016-03-01 Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery Schaub, Jennifer A. Garg, Amit X. Coca, Steven G. Testani, Jeffrey M. Shlipak, Michael G. Eikelboom, John Kavsak, Peter McArthur, Eric Shortt, Colleen Whitlock, Richard Parikh, Chirag R. Kidney Int Article Acute Kidney Injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. Since heart fatty acid binding protein (H-FABP) is a myocardial protein that detects cardiac injury, we sought to determine if plasma H-FABP was associated with AKI in the TRIBE-AKI cohort; a multi-center cohort of 1219 patients at high risk for AKI who underwent cardiac surgery. The primary outcomes of interest were any AKI (Acute Kidney Injury Network (AKIN) stage 1 or higher) and severe AKI (AKIN stage 2 or higher). The secondary outcome was long-term mortality after discharge. Patients who developed AKI had higher levels of H-FABP pre- and post-operatively than patients who did not have AKI. In analyses adjusted for known AKI risk factors, first post-operative log(H-FABP) was associated with severe AKI (adjusted OR 5.39 [95% CI, 2.87-10.11] per unit increase), while pre-operative log(H-FABP) was associated with any AKI (2.07 [1.48-2.89]) and mortality (1.67 [1.17-2.37]). These relationships persisted after adjustment for change in serum creatinine (for first postoperative log(H-FABP)) and biomarkers of cardiac and kidney injury, including brain natriuretic peptide, cardiac troponin-I, interleukin-18, liver fatty acid binding protein, kidney injury molecule-1, and neutrophil gelatinase associated lipocalin. Thus, peri-operative plasma H-FABP levels may be used for risk-stratification of AKI and mortality following cardiac surgery. 2015-04-01 2015-09 /pmc/articles/PMC4556547/ /pubmed/25830762 http://dx.doi.org/10.1038/ki.2015.104 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Schaub, Jennifer A.
Garg, Amit X.
Coca, Steven G.
Testani, Jeffrey M.
Shlipak, Michael G.
Eikelboom, John
Kavsak, Peter
McArthur, Eric
Shortt, Colleen
Whitlock, Richard
Parikh, Chirag R.
Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title_full Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title_fullStr Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title_full_unstemmed Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title_short Peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
title_sort peri-operative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556547/
https://www.ncbi.nlm.nih.gov/pubmed/25830762
http://dx.doi.org/10.1038/ki.2015.104
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