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Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells
Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but the cellular target that mediates its profibrotic actions has not been clearly identified. While in vitro data suggest that TGF-β-induced matrix production is mediated by renal fibroblasts, the role of thes...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556568/ https://www.ncbi.nlm.nih.gov/pubmed/25760325 http://dx.doi.org/10.1038/ki.2015.51 |