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Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates

The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which an inhibitor (perpetrator) drug decreases OCT2-dependent renal clearance of a victim (substrate) drug. In fact, there are clinically signifi...

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Detalles Bibliográficos
Autores principales:	Hacker, Kristina, Maas, Renke, Kornhuber, Johannes, Fromm, Martin F., Zolk, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556614/ https://www.ncbi.nlm.nih.gov/pubmed/26327616 http://dx.doi.org/10.1371/journal.pone.0136451

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