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Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents
Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556734/ https://www.ncbi.nlm.nih.gov/pubmed/26413477 http://dx.doi.org/10.1016/j.nicl.2015.07.015 |
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author | Moseley, R.L. Ypma, R.J.F. Holt, R.J. Floris, D. Chura, L.R. Spencer, M.D. Baron-Cohen, S. Suckling, J. Bullmore, E. Rubinov, M. |
author_facet | Moseley, R.L. Ypma, R.J.F. Holt, R.J. Floris, D. Chura, L.R. Spencer, M.D. Baron-Cohen, S. Suckling, J. Bullmore, E. Rubinov, M. |
author_sort | Moseley, R.L. |
collection | PubMed |
description | Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent males with autism, genetically-related siblings of individuals with autism, and typically-developing control participants. We parcellated the brain into 258 regions and used complex-network analysis to detect a robust hypoconnectivity endophenotype in our participant group. We observed that whole-brain functional connectivity was highest in controls, intermediate in siblings, and lowest in ASC, in task and rest conditions. We identified additional, local endophenotype effects in specific networks including the visual processing and default mode networks. Our analyses are the first to show that whole-brain functional hypoconnectivity is an endophenotype of autism in adolescence, and may thus underlie the heritable similarities seen in adolescents with ASC and their relatives. |
format | Online Article Text |
id | pubmed-4556734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-45567342015-09-25 Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents Moseley, R.L. Ypma, R.J.F. Holt, R.J. Floris, D. Chura, L.R. Spencer, M.D. Baron-Cohen, S. Suckling, J. Bullmore, E. Rubinov, M. Neuroimage Clin Regular Article Endophenotypes are heritable and quantifiable markers that may assist in the identification of the complex genetic underpinnings of psychiatric conditions. Here we examined global hypoconnectivity as an endophenotype of autism spectrum conditions (ASCs). We studied well-matched groups of adolescent males with autism, genetically-related siblings of individuals with autism, and typically-developing control participants. We parcellated the brain into 258 regions and used complex-network analysis to detect a robust hypoconnectivity endophenotype in our participant group. We observed that whole-brain functional connectivity was highest in controls, intermediate in siblings, and lowest in ASC, in task and rest conditions. We identified additional, local endophenotype effects in specific networks including the visual processing and default mode networks. Our analyses are the first to show that whole-brain functional hypoconnectivity is an endophenotype of autism in adolescence, and may thus underlie the heritable similarities seen in adolescents with ASC and their relatives. Elsevier 2015-08-07 /pmc/articles/PMC4556734/ /pubmed/26413477 http://dx.doi.org/10.1016/j.nicl.2015.07.015 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Moseley, R.L. Ypma, R.J.F. Holt, R.J. Floris, D. Chura, L.R. Spencer, M.D. Baron-Cohen, S. Suckling, J. Bullmore, E. Rubinov, M. Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title | Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title_full | Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title_fullStr | Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title_full_unstemmed | Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title_short | Whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
title_sort | whole-brain functional hypoconnectivity as an endophenotype of autism in adolescents |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556734/ https://www.ncbi.nlm.nih.gov/pubmed/26413477 http://dx.doi.org/10.1016/j.nicl.2015.07.015 |
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