Anticonvulsant-induced downbeat nystagmus in epilepsy

We report data from two patients who developed reversible downbeat nystagmus (DBN) while using AEDs within the therapeutic range. All previous reported cases of epilepsy with drug-induced DBN related to toxic levels of AEDs were summarized, and DBN was found mostly occurring in those using a sodium...

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Detalles Bibliográficos
Autores principales: Wu, Dongyan, Thijs, Roland D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556747/
https://www.ncbi.nlm.nih.gov/pubmed/26543808
http://dx.doi.org/10.1016/j.ebcr.2015.07.003
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author Wu, Dongyan
Thijs, Roland D.
author_facet Wu, Dongyan
Thijs, Roland D.
author_sort Wu, Dongyan
collection PubMed
description We report data from two patients who developed reversible downbeat nystagmus (DBN) while using AEDs within the therapeutic range. All previous reported cases of epilepsy with drug-induced DBN related to toxic levels of AEDs were summarized, and DBN was found mostly occurring in those using a sodium channel blocking AED. We propose that in our cases, the DBN with therapeutic AED levels may be explained by additive effects of sodium channel blockers. Adverse drug effects should be considered as a cause of DBN in people with epilepsy treated with multiple AEDs.
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spelling pubmed-45567472015-11-05 Anticonvulsant-induced downbeat nystagmus in epilepsy Wu, Dongyan Thijs, Roland D. Epilepsy Behav Case Rep Case Report We report data from two patients who developed reversible downbeat nystagmus (DBN) while using AEDs within the therapeutic range. All previous reported cases of epilepsy with drug-induced DBN related to toxic levels of AEDs were summarized, and DBN was found mostly occurring in those using a sodium channel blocking AED. We propose that in our cases, the DBN with therapeutic AED levels may be explained by additive effects of sodium channel blockers. Adverse drug effects should be considered as a cause of DBN in people with epilepsy treated with multiple AEDs. Elsevier 2015-08-27 /pmc/articles/PMC4556747/ /pubmed/26543808 http://dx.doi.org/10.1016/j.ebcr.2015.07.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wu, Dongyan
Thijs, Roland D.
Anticonvulsant-induced downbeat nystagmus in epilepsy
title Anticonvulsant-induced downbeat nystagmus in epilepsy
title_full Anticonvulsant-induced downbeat nystagmus in epilepsy
title_fullStr Anticonvulsant-induced downbeat nystagmus in epilepsy
title_full_unstemmed Anticonvulsant-induced downbeat nystagmus in epilepsy
title_short Anticonvulsant-induced downbeat nystagmus in epilepsy
title_sort anticonvulsant-induced downbeat nystagmus in epilepsy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556747/
https://www.ncbi.nlm.nih.gov/pubmed/26543808
http://dx.doi.org/10.1016/j.ebcr.2015.07.003
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