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Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling()

We recently reported the synthesis of NOSH-aspirin, a novel hybrid that releases both nitric oxide (NO) and hydrogen sulfide (H(2)S). In NOSH-aspirin, the two moieties that release NO and H(2)S are covalently linked at the 1, 2 positions of acetyl salicylic acid, i.e. ortho-NOSH-aspirin (o-NOSH-aspi...

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Detalles Bibliográficos
Autores principales:	Vannini, Federica, Chattopadhyay, Mitali, Kodela, Ravinder, Rao, Praveen P.N., Kashfi, Khosrow
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556775/ https://www.ncbi.nlm.nih.gov/pubmed/26319435 http://dx.doi.org/10.1016/j.redox.2015.08.014

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