Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells

Here we provide raw and processed data and methods behind mTOR siRNA loaded DNA nanotubes (siRNA-DNA-NTs) in the growth of pulmonary arterial smooth muscle cells (PASMCs) under both normoxic and hypoxic condition, and also related to (You et al., Biomaterials, 2015, 67:137–150, [1]). The MTT analysi...

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Detalles Bibliográficos
Autores principales: You, Zaichun, Qian, Hang, Wang, Changzheng, He, Binfeng, Yan, Jiawei, Mao, Chengde, Wang, Guansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556778/
https://www.ncbi.nlm.nih.gov/pubmed/26380842
http://dx.doi.org/10.1016/j.dib.2015.08.002
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author You, Zaichun
Qian, Hang
Wang, Changzheng
He, Binfeng
Yan, Jiawei
Mao, Chengde
Wang, Guansong
author_facet You, Zaichun
Qian, Hang
Wang, Changzheng
He, Binfeng
Yan, Jiawei
Mao, Chengde
Wang, Guansong
author_sort You, Zaichun
collection PubMed
description Here we provide raw and processed data and methods behind mTOR siRNA loaded DNA nanotubes (siRNA-DNA-NTs) in the growth of pulmonary arterial smooth muscle cells (PASMCs) under both normoxic and hypoxic condition, and also related to (You et al., Biomaterials, 2015, 67:137–150, [1]). The MTT analysis, Semi-quantitative RT-PCR data presented here were used to probe cytotoxicity of mTOR siRNA-DNA-NT complex in its TAE-Mg(2+) buffer. siRNA-DNA-NTs have a lower cytotoxicity and higher transfection efficiency and can, based on inhibition of mTOR expression, decrease PASMCs growth both hypoxic and normal condition.
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spelling pubmed-45567782015-09-17 Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells You, Zaichun Qian, Hang Wang, Changzheng He, Binfeng Yan, Jiawei Mao, Chengde Wang, Guansong Data Brief Data Article Here we provide raw and processed data and methods behind mTOR siRNA loaded DNA nanotubes (siRNA-DNA-NTs) in the growth of pulmonary arterial smooth muscle cells (PASMCs) under both normoxic and hypoxic condition, and also related to (You et al., Biomaterials, 2015, 67:137–150, [1]). The MTT analysis, Semi-quantitative RT-PCR data presented here were used to probe cytotoxicity of mTOR siRNA-DNA-NT complex in its TAE-Mg(2+) buffer. siRNA-DNA-NTs have a lower cytotoxicity and higher transfection efficiency and can, based on inhibition of mTOR expression, decrease PASMCs growth both hypoxic and normal condition. Elsevier 2015-08-15 /pmc/articles/PMC4556778/ /pubmed/26380842 http://dx.doi.org/10.1016/j.dib.2015.08.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
You, Zaichun
Qian, Hang
Wang, Changzheng
He, Binfeng
Yan, Jiawei
Mao, Chengde
Wang, Guansong
Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title_full Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title_fullStr Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title_full_unstemmed Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title_short Inhibition of DNA nanotube-conjugated mTOR siRNA on the growth of pulmonary arterial smooth muscle cells
title_sort inhibition of dna nanotube-conjugated mtor sirna on the growth of pulmonary arterial smooth muscle cells
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556778/
https://www.ncbi.nlm.nih.gov/pubmed/26380842
http://dx.doi.org/10.1016/j.dib.2015.08.002
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