The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop

Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by accumulation of NS polymers. Our Molecular Dynamics si...

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Detalles Bibliográficos
Autores principales: Noto, Rosina, Randazzo, Loredana, Raccosta, Samuele, Caccia, Sonia, Moriconi, Claudia, Miranda, Elena, Martorana, Vincenzo, Manno, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556959/
https://www.ncbi.nlm.nih.gov/pubmed/26329378
http://dx.doi.org/10.1038/srep13666

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