Marine Indole Alkaloids

Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplasti...

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Detalles Bibliográficos
Autores principales: Netz, Natalie, Opatz, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557006/
https://www.ncbi.nlm.nih.gov/pubmed/26287214
http://dx.doi.org/10.3390/md13084814
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author Netz, Natalie
Opatz, Till
author_facet Netz, Natalie
Opatz, Till
author_sort Netz, Natalie
collection PubMed
description Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.
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spelling pubmed-45570062015-09-03 Marine Indole Alkaloids Netz, Natalie Opatz, Till Mar Drugs Review Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed. MDPI 2015-08-06 /pmc/articles/PMC4557006/ /pubmed/26287214 http://dx.doi.org/10.3390/md13084814 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Netz, Natalie
Opatz, Till
Marine Indole Alkaloids
title Marine Indole Alkaloids
title_full Marine Indole Alkaloids
title_fullStr Marine Indole Alkaloids
title_full_unstemmed Marine Indole Alkaloids
title_short Marine Indole Alkaloids
title_sort marine indole alkaloids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557006/
https://www.ncbi.nlm.nih.gov/pubmed/26287214
http://dx.doi.org/10.3390/md13084814
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