Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs

N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid me...

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Autores principales: Osaki, Tomohiro, Kurozumi, Seiji, Sato, Kimihiko, Terashi, Taro, Azuma, Kazuo, Murahata, Yusuke, Tsuka, Takeshi, Ito, Norihiko, Imagawa, Tomohiro, Minami, Saburo, Okamoto, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557012/
https://www.ncbi.nlm.nih.gov/pubmed/26262626
http://dx.doi.org/10.3390/md13085007
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author Osaki, Tomohiro
Kurozumi, Seiji
Sato, Kimihiko
Terashi, Taro
Azuma, Kazuo
Murahata, Yusuke
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Minami, Saburo
Okamoto, Yoshiharu
author_facet Osaki, Tomohiro
Kurozumi, Seiji
Sato, Kimihiko
Terashi, Taro
Azuma, Kazuo
Murahata, Yusuke
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Minami, Saburo
Okamoto, Yoshiharu
author_sort Osaki, Tomohiro
collection PubMed
description N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism.
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spelling pubmed-45570122015-09-03 Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs Osaki, Tomohiro Kurozumi, Seiji Sato, Kimihiko Terashi, Taro Azuma, Kazuo Murahata, Yusuke Tsuka, Takeshi Ito, Norihiko Imagawa, Tomohiro Minami, Saburo Okamoto, Yoshiharu Mar Drugs Article N-acetyl-d-glucosamine (GlcNAc) is a monosaccharide that polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. GlcNAc is a basic component of hyaluronic acid and keratin sulfate found on the cell surface. The aim of this study was to examine amino acid metabolism after oral GlcNAc administration in dogs. Results showed that plasma levels of ectoine were significantly higher after oral administration of GlcNAc than prior to administration (p < 0.001). To our knowledge, there have been no reports of increased ectoine concentrations in the plasma. The mechanism by which GlcNAc administration leads to increased ectoine plasma concentration remains unclear; future studies are required to clarify this mechanism. MDPI 2015-08-07 /pmc/articles/PMC4557012/ /pubmed/26262626 http://dx.doi.org/10.3390/md13085007 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Osaki, Tomohiro
Kurozumi, Seiji
Sato, Kimihiko
Terashi, Taro
Azuma, Kazuo
Murahata, Yusuke
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Minami, Saburo
Okamoto, Yoshiharu
Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title_full Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title_fullStr Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title_full_unstemmed Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title_short Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs
title_sort metabolomic analysis of blood plasma after oral administration of n-acetyl-d-glucosamine in dogs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557012/
https://www.ncbi.nlm.nih.gov/pubmed/26262626
http://dx.doi.org/10.3390/md13085007
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