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Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.

Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomy...

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Autores principales: Bae, Munhyung, Chung, Beomkoo, Oh, Ki-Bong, Shin, Jongheon, Oh, Dong-Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557019/
https://www.ncbi.nlm.nih.gov/pubmed/26287218
http://dx.doi.org/10.3390/md13085187
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author Bae, Munhyung
Chung, Beomkoo
Oh, Ki-Bong
Shin, Jongheon
Oh, Dong-Chan
author_facet Bae, Munhyung
Chung, Beomkoo
Oh, Ki-Bong
Shin, Jongheon
Oh, Dong-Chan
author_sort Bae, Munhyung
collection PubMed
description Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and β-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria.
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spelling pubmed-45570192015-09-03 Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp. Bae, Munhyung Chung, Beomkoo Oh, Ki-Bong Shin, Jongheon Oh, Dong-Chan Mar Drugs Article Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and β-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria. MDPI 2015-08-14 /pmc/articles/PMC4557019/ /pubmed/26287218 http://dx.doi.org/10.3390/md13085187 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bae, Munhyung
Chung, Beomkoo
Oh, Ki-Bong
Shin, Jongheon
Oh, Dong-Chan
Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title_full Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title_fullStr Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title_full_unstemmed Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title_short Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
title_sort hormaomycins b and c: new antibiotic cyclic depsipeptides from a marine mudflat-derived streptomyces sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557019/
https://www.ncbi.nlm.nih.gov/pubmed/26287218
http://dx.doi.org/10.3390/md13085187
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