Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus making the development of PPI inhibitors extremely valuable. The identification of selective inhibitors is challenging because of the shallow and extended nature of PPI interfaces. Inhibitors can be obtaine...

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Detalles Bibliográficos
Autores principales: Pelay-Gimeno, Marta, Glas, Adrian, Koch, Oliver, Grossmann, Tom N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557054/
https://www.ncbi.nlm.nih.gov/pubmed/26119925
http://dx.doi.org/10.1002/anie.201412070

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