Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity

G-quadruplexes formed in telomeric DNA sequences at human chromosome ends can be a novel target for the development of therapeutics for the treatment of cancer patients. Herein, we examined the ability of six novel benzothioxanthene derivatives S1–S6 to induce the formation of and stabilize an antip...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Chen, Min, Ling Wu, Yan, Tanaka, Yoshimasa, Juan Ji, Yan, Lin Zhang, Su, He Wei, Chuan, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557076/
https://www.ncbi.nlm.nih.gov/pubmed/26329134
http://dx.doi.org/10.1038/srep13693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557076/
https://www.ncbi.nlm.nih.gov/pubmed/26329134
http://dx.doi.org/10.1038/srep13693

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