Hypermetabolism of Olivary Nuclei in a Patient with Progressive Ataxia and Palatal Tremor

BACKGROUND: The pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT) is unclear. CASE REPORT: A 77-year-old male presented with dysarthria, ataxia, and 1–2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was...

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Detalles Bibliográficos
Autores principales: Korpela, Jaana, Joutsa, Juho, Rinne, Juha O., Bergman, Jörgen, Kaasinen, Valtteri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Columbia University Libraries/Information Services 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557084/
https://www.ncbi.nlm.nih.gov/pubmed/26339529
http://dx.doi.org/10.7916/D8PV6JMT
Descripción
Sumario:BACKGROUND: The pathophysiology of the movement disorder progressive ataxia with palatal tremor (PAPT) is unclear. CASE REPORT: A 77-year-old male presented with dysarthria, ataxia, and 1–2 Hz palatal tremor. A diagnosis of probable sporadic PAPT was established. Brain magnetic resonance imaging was normal at the presymptomatic phase but later showed olivary hypertrophy. Brain [(18)F]-fludeoxyglucose (FDG) positron emission tomography (PET) showed bilateral hypermetabolism in the olivary nuclei. DISCUSSION: This second reported patient with PAPT and FDG-PET shows that olivary hypertrophy is paralleled with hypermetabolism. The olivary nuclei pathology also appears to be temporally associated with symptom onset.

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