Cargando…
Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate
There is currently no therapeutic drug treatment for traumatic brain injury (TBI) despite decades of experimental clinical trials. This may be because the mechanistic pathways for improving TBI outcomes have yet to be identified and exploited. As such, there remains a need to seek out new molecular...
Autores principales: | Hook, Gregory, Jacobsen, J. Steven, Grabstein, Kenneth, Kindy, Mark, Hook, Vivian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557097/ https://www.ncbi.nlm.nih.gov/pubmed/26388830 http://dx.doi.org/10.3389/fneur.2015.00178 |
Ejemplares similares
-
Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition
por: Hook, Gregory, et al.
Publicado: (2023) -
Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production
por: Podvin, Sonia, et al.
Publicado: (2018) -
Distinct Cleavage
Properties of Cathepsin B Compared
to Cysteine Cathepsins Enable the Design and Validation of a Specific
Substrate for Cathepsin B over a Broad pH Range
por: Yoon, Michael C., et al.
Publicado: (2023) -
Cathepsin B
Dipeptidyl Carboxypeptidase and Endopeptidase
Activities Demonstrated across a Broad pH Range
por: Yoon, Michael C., et al.
Publicado: (2022) -
Promising Lead Compounds in the Development of Potential Clinical Drug Candidate for Drug-Resistant Tuberculosis
por: Alghamdi, Saad, et al.
Publicado: (2020)