TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

High insulin/IGF is a biologic link between diabetes and cancers, but the underlying molecular mechanism remains unclear. Here we report a previously unrecognized tumour-promoting mechanism for stress protein TRB3, which mediates a reciprocal antagonism between autophagic and proteasomal degradation...

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Detalles Bibliográficos
Autores principales: Hua, Fang, Li, Ke, Yu, Jiao-Jiao, Lv, Xiao-Xi, Yan, Jun, Zhang, Xiao-Wei, Sun, Wei, Lin, Heng, Shang, Shuang, Wang, Feng, Cui, Bing, Mu, Rong, Huang, Bo, Jiang, Jian-Dong, Hu, Zhuo-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557121/
https://www.ncbi.nlm.nih.gov/pubmed/26268733
http://dx.doi.org/10.1038/ncomms8951

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