A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signa...

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Detalles Bibliográficos
Autores principales: Uno, Kenji, Yamada, Tetsuya, Ishigaki, Yasushi, Imai, Junta, Hasegawa, Yutaka, Sawada, Shojiro, Kaneko, Keizo, Ono, Hiraku, Asano, Tomoichiro, Oka, Yoshitomo, Katagiri, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557134/
https://www.ncbi.nlm.nih.gov/pubmed/26268630
http://dx.doi.org/10.1038/ncomms8940

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