In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22

Mutations in the proteins that bind insulator DNA elements that define the boundaries of chromatin domains can give morphogenetic readouts in Drosophila, as recently reported in BMC Biology by Bonchuk et al. in the Georgiev laboratory. But disentangling the effects on the phenotype may not be simple...

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Detalles Bibliográficos
Autor principal: Karch, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557222/
https://www.ncbi.nlm.nih.gov/pubmed/26329471
http://dx.doi.org/10.1186/s12915-015-0182-9
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author Karch, François
author_facet Karch, François
author_sort Karch, François
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description Mutations in the proteins that bind insulator DNA elements that define the boundaries of chromatin domains can give morphogenetic readouts in Drosophila, as recently reported in BMC Biology by Bonchuk et al. in the Georgiev laboratory. But disentangling the effects on the phenotype may not be simple. See research article: http://www.biomedcentral.com/1741-7007/13/63
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spelling pubmed-45572222015-09-03 In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22 Karch, François BMC Biol Commentary Mutations in the proteins that bind insulator DNA elements that define the boundaries of chromatin domains can give morphogenetic readouts in Drosophila, as recently reported in BMC Biology by Bonchuk et al. in the Georgiev laboratory. But disentangling the effects on the phenotype may not be simple. See research article: http://www.biomedcentral.com/1741-7007/13/63 BioMed Central 2015-09-02 /pmc/articles/PMC4557222/ /pubmed/26329471 http://dx.doi.org/10.1186/s12915-015-0182-9 Text en © Karch. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Karch, François
In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title_full In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title_fullStr In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title_full_unstemmed In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title_short In vivo studies of the Drosophila insulator factor CTCF reach a Catch 22
title_sort in vivo studies of the drosophila insulator factor ctcf reach a catch 22
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557222/
https://www.ncbi.nlm.nih.gov/pubmed/26329471
http://dx.doi.org/10.1186/s12915-015-0182-9
work_keys_str_mv AT karchfrancois invivostudiesofthedrosophilainsulatorfactorctcfreachacatch22

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