Cargando…

A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran

BACKGROUND & OBJECTIVES: Inherited thrombophilia is known to be an important risk factor for developing venous thromboembolism. Whether such abnormalities may impact the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) differently is not well defined. This preliminary study...

Descripción completa

Detalles Bibliográficos
Autores principales: Karimi, Ali, Abolhasani, Marziyeh, Hashemzadeh-Chaleshtori, Morteza, Pourgheysari, Batoul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557250/
https://www.ncbi.nlm.nih.gov/pubmed/26261166
http://dx.doi.org/10.4103/0971-5916.162096
_version_ 1782388474543865856
author Karimi, Ali
Abolhasani, Marziyeh
Hashemzadeh-Chaleshtori, Morteza
Pourgheysari, Batoul
author_facet Karimi, Ali
Abolhasani, Marziyeh
Hashemzadeh-Chaleshtori, Morteza
Pourgheysari, Batoul
author_sort Karimi, Ali
collection PubMed
description BACKGROUND & OBJECTIVES: Inherited thrombophilia is known to be an important risk factor for developing venous thromboembolism. Whether such abnormalities may impact the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) differently is not well defined. This preliminary study was undertaken to compare thrombophilic polymorphism in patients with DVT and PE. METHODS: A total of 35 DVT, 23 DVT/PE, and 37 PE patients admitted to the Hajar Hospital, Shahrekord, Iran, between October 2009 and February 2011 were included in the study and 306 healthy volunteers matched by age and sex from the same geographical area with no history of venous or arterial diseases were included as control group. Factor V Leiden (FV 1691G/A, rs6025), prothrombin (FII 20210G/A), methylene tetrahydrofulate reductase (MTHFR 677C/T, rs1801133), and PLA2 polymorphisms of platelet glycoprotein IIb/IIIa (GpIIIa 1565T/C, rs5918) were investigated by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The number of patients with the investigated polymorphisms and homozygous carriers was significantly different among the groups (P<0.05). No significant difference was observed in the presence of FV 1691G/A and FII 20210G/A between any of the patients groups and the control group. GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively). INTERPRETATION & CONCLUSIONS: As none of the investigated polymorphisms were associated with PE, other thrombophilia polymorphisms may have a role in the pathogenesis of PE in these patients and should be investigated. Because of different prognostic risk factors among different types of patients, the treatment approach could be different.
format Online
Article
Text
id pubmed-4557250
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-45572502015-09-21 A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran Karimi, Ali Abolhasani, Marziyeh Hashemzadeh-Chaleshtori, Morteza Pourgheysari, Batoul Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Inherited thrombophilia is known to be an important risk factor for developing venous thromboembolism. Whether such abnormalities may impact the development of deep vein thrombosis (DVT) and pulmonary embolism (PE) differently is not well defined. This preliminary study was undertaken to compare thrombophilic polymorphism in patients with DVT and PE. METHODS: A total of 35 DVT, 23 DVT/PE, and 37 PE patients admitted to the Hajar Hospital, Shahrekord, Iran, between October 2009 and February 2011 were included in the study and 306 healthy volunteers matched by age and sex from the same geographical area with no history of venous or arterial diseases were included as control group. Factor V Leiden (FV 1691G/A, rs6025), prothrombin (FII 20210G/A), methylene tetrahydrofulate reductase (MTHFR 677C/T, rs1801133), and PLA2 polymorphisms of platelet glycoprotein IIb/IIIa (GpIIIa 1565T/C, rs5918) were investigated by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The number of patients with the investigated polymorphisms and homozygous carriers was significantly different among the groups (P<0.05). No significant difference was observed in the presence of FV 1691G/A and FII 20210G/A between any of the patients groups and the control group. GpIIIa 1565T/C and homozygous MTHFR 677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively). INTERPRETATION & CONCLUSIONS: As none of the investigated polymorphisms were associated with PE, other thrombophilia polymorphisms may have a role in the pathogenesis of PE in these patients and should be investigated. Because of different prognostic risk factors among different types of patients, the treatment approach could be different. Medknow Publications & Media Pvt Ltd 2015-07 /pmc/articles/PMC4557250/ /pubmed/26261166 http://dx.doi.org/10.4103/0971-5916.162096 Text en Copyright: © Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Karimi, Ali
Abolhasani, Marziyeh
Hashemzadeh-Chaleshtori, Morteza
Pourgheysari, Batoul
A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title_full A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title_fullStr A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title_full_unstemmed A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title_short A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran
title_sort preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557250/
https://www.ncbi.nlm.nih.gov/pubmed/26261166
http://dx.doi.org/10.4103/0971-5916.162096
work_keys_str_mv AT karimiali apreliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT abolhasanimarziyeh apreliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT hashemzadehchaleshtorimorteza apreliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT pourgheysaribatoul apreliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT karimiali preliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT abolhasanimarziyeh preliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT hashemzadehchaleshtorimorteza preliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran
AT pourgheysaribatoul preliminarystudyofinheritedthrombophilicriskfactorsindifferentclinicalmanifestationsofvenousthromboembolismincentraliran