Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS

Ca(2+) signals are highly regulated in a spatiotemporal manner in numerous cellular physiological events. Here we report a genetically engineered blue light-activated Ca(2+) channel switch (BACCS), as an optogenetic tool for generating Ca(2+) signals. BACCS opens Ca(2+)-selective ORAI ion channels i...

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Detalles Bibliográficos
Autores principales: Ishii, Tomohiro, Sato, Koji, Kakumoto, Toshiyuki, Miura, Shigenori, Touhara, Kazushige, Takeuchi, Shoji, Nakata, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557345/
https://www.ncbi.nlm.nih.gov/pubmed/26282514
http://dx.doi.org/10.1038/ncomms9021

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