The impact of DNA intercalators on DNA and DNA-processing enzymes elucidated through force-dependent binding kinetics

DNA intercalators are widely used as fluorescent probes to visualize DNA and DNA transactions in vivo and in vitro. It is well known that they perturb DNA structure and stability, which can in turn influence DNA-processing by proteins. Here we elucidate this perturbation by combining single-dye fluo...

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Detalles Bibliográficos
Autores principales: Biebricher, Andreas S., Heller, Iddo, Roijmans, Roel F. H., Hoekstra, Tjalle P., Peterman, Erwin J. G., Wuite, Gijs J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557362/
https://www.ncbi.nlm.nih.gov/pubmed/26084388
http://dx.doi.org/10.1038/ncomms8304

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