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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further t...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485/ https://www.ncbi.nlm.nih.gov/pubmed/26237428 http://dx.doi.org/10.1038/ng.3373 |
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| author | Law, Matthew H. Bishop, D. Timothy Lee, Jeffrey E. Brossard, Myriam Martin, Nicholas G. Moses, Eric K. Song, Fengju Barrett, Jennifer H. Kumar, Rajiv Easton, Douglas F. Pharoah, Paul D. P. Swerdlow, Anthony J. Kypreou, Katerina P. Taylor, John C. Harland, Mark Randerson-Moor, Juliette Akslen, Lars A. Andresen, Per A. Avril, Marie-Françoise Azizi, Esther Scarrà, Giovanna Bianchi Brown, Kevin M. Dębniak, Tadeusz Duffy, David L. Elder, David E. Fang, Shenying Friedman, Eitan Galan, Pilar Ghiorzo, Paola Gillanders, Elizabeth M. Goldstein, Alisa M. Gruis, Nelleke A. Hansson, Johan Helsing, Per Hočevar, Marko Höiom, Veronica Ingvar, Christian Kanetsky, Peter A. Chen, Wei V. Landi, Maria Teresa Lang, Julie Lathrop, G. Mark Lubiński, Jan Mackie, Rona M. Mann, Graham J. Molven, Anders Montgomery, Grant W. Novaković, Srdjan Olsson, Håkan Puig, Susana Puig-Butille, Joan Anton Qureshi, Abrar A. Radford-Smith, Graham L. van der Stoep, Nienke van Doorn, Remco Whiteman, David C. Craig, Jamie E. Schadendorf, Dirk Simms, Lisa A. Burdon, Kathryn P. Nyholt, Dale R. Pooley, Karen A. Orr, Nick Stratigos, Alexander J. Cust, Anne E. Ward, Sarah V. Hayward, Nicholas K. Han, Jiali Schulze, Hans-Joachim Dunning, Alison M. Bishop, Julia A. Newton Demenais, Florence Amos, Christopher I. MacGregor, Stuart Iles, Mark M. |
| author_facet | Law, Matthew H. Bishop, D. Timothy Lee, Jeffrey E. Brossard, Myriam Martin, Nicholas G. Moses, Eric K. Song, Fengju Barrett, Jennifer H. Kumar, Rajiv Easton, Douglas F. Pharoah, Paul D. P. Swerdlow, Anthony J. Kypreou, Katerina P. Taylor, John C. Harland, Mark Randerson-Moor, Juliette Akslen, Lars A. Andresen, Per A. Avril, Marie-Françoise Azizi, Esther Scarrà, Giovanna Bianchi Brown, Kevin M. Dębniak, Tadeusz Duffy, David L. Elder, David E. Fang, Shenying Friedman, Eitan Galan, Pilar Ghiorzo, Paola Gillanders, Elizabeth M. Goldstein, Alisa M. Gruis, Nelleke A. Hansson, Johan Helsing, Per Hočevar, Marko Höiom, Veronica Ingvar, Christian Kanetsky, Peter A. Chen, Wei V. Landi, Maria Teresa Lang, Julie Lathrop, G. Mark Lubiński, Jan Mackie, Rona M. Mann, Graham J. Molven, Anders Montgomery, Grant W. Novaković, Srdjan Olsson, Håkan Puig, Susana Puig-Butille, Joan Anton Qureshi, Abrar A. Radford-Smith, Graham L. van der Stoep, Nienke van Doorn, Remco Whiteman, David C. Craig, Jamie E. Schadendorf, Dirk Simms, Lisa A. Burdon, Kathryn P. Nyholt, Dale R. Pooley, Karen A. Orr, Nick Stratigos, Alexander J. Cust, Anne E. Ward, Sarah V. Hayward, Nicholas K. Han, Jiali Schulze, Hans-Joachim Dunning, Alison M. Bishop, Julia A. Newton Demenais, Florence Amos, Christopher I. MacGregor, Stuart Iles, Mark M. |
| author_sort | Law, Matthew H. |
| collection | PubMed |
| description | Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5×10(–8)), as did two previously-reported but un-replicated loci and all thirteen established loci. Novel SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes including one involved in telomere biology. |
| format | Online Article Text |
| id | pubmed-4557485 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-45574852016-03-01 Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma Law, Matthew H. Bishop, D. Timothy Lee, Jeffrey E. Brossard, Myriam Martin, Nicholas G. Moses, Eric K. Song, Fengju Barrett, Jennifer H. Kumar, Rajiv Easton, Douglas F. Pharoah, Paul D. P. Swerdlow, Anthony J. Kypreou, Katerina P. Taylor, John C. Harland, Mark Randerson-Moor, Juliette Akslen, Lars A. Andresen, Per A. Avril, Marie-Françoise Azizi, Esther Scarrà, Giovanna Bianchi Brown, Kevin M. Dębniak, Tadeusz Duffy, David L. Elder, David E. Fang, Shenying Friedman, Eitan Galan, Pilar Ghiorzo, Paola Gillanders, Elizabeth M. Goldstein, Alisa M. Gruis, Nelleke A. Hansson, Johan Helsing, Per Hočevar, Marko Höiom, Veronica Ingvar, Christian Kanetsky, Peter A. Chen, Wei V. Landi, Maria Teresa Lang, Julie Lathrop, G. Mark Lubiński, Jan Mackie, Rona M. Mann, Graham J. Molven, Anders Montgomery, Grant W. Novaković, Srdjan Olsson, Håkan Puig, Susana Puig-Butille, Joan Anton Qureshi, Abrar A. Radford-Smith, Graham L. van der Stoep, Nienke van Doorn, Remco Whiteman, David C. Craig, Jamie E. Schadendorf, Dirk Simms, Lisa A. Burdon, Kathryn P. Nyholt, Dale R. Pooley, Karen A. Orr, Nick Stratigos, Alexander J. Cust, Anne E. Ward, Sarah V. Hayward, Nicholas K. Han, Jiali Schulze, Hans-Joachim Dunning, Alison M. Bishop, Julia A. Newton Demenais, Florence Amos, Christopher I. MacGregor, Stuart Iles, Mark M. Nat Genet Article Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5×10(–8)), as did two previously-reported but un-replicated loci and all thirteen established loci. Novel SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes including one involved in telomere biology. 2015-08-03 2015-09 /pmc/articles/PMC4557485/ /pubmed/26237428 http://dx.doi.org/10.1038/ng.3373 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Law, Matthew H. Bishop, D. Timothy Lee, Jeffrey E. Brossard, Myriam Martin, Nicholas G. Moses, Eric K. Song, Fengju Barrett, Jennifer H. Kumar, Rajiv Easton, Douglas F. Pharoah, Paul D. P. Swerdlow, Anthony J. Kypreou, Katerina P. Taylor, John C. Harland, Mark Randerson-Moor, Juliette Akslen, Lars A. Andresen, Per A. Avril, Marie-Françoise Azizi, Esther Scarrà, Giovanna Bianchi Brown, Kevin M. Dębniak, Tadeusz Duffy, David L. Elder, David E. Fang, Shenying Friedman, Eitan Galan, Pilar Ghiorzo, Paola Gillanders, Elizabeth M. Goldstein, Alisa M. Gruis, Nelleke A. Hansson, Johan Helsing, Per Hočevar, Marko Höiom, Veronica Ingvar, Christian Kanetsky, Peter A. Chen, Wei V. Landi, Maria Teresa Lang, Julie Lathrop, G. Mark Lubiński, Jan Mackie, Rona M. Mann, Graham J. Molven, Anders Montgomery, Grant W. Novaković, Srdjan Olsson, Håkan Puig, Susana Puig-Butille, Joan Anton Qureshi, Abrar A. Radford-Smith, Graham L. van der Stoep, Nienke van Doorn, Remco Whiteman, David C. Craig, Jamie E. Schadendorf, Dirk Simms, Lisa A. Burdon, Kathryn P. Nyholt, Dale R. Pooley, Karen A. Orr, Nick Stratigos, Alexander J. Cust, Anne E. Ward, Sarah V. Hayward, Nicholas K. Han, Jiali Schulze, Hans-Joachim Dunning, Alison M. Bishop, Julia A. Newton Demenais, Florence Amos, Christopher I. MacGregor, Stuart Iles, Mark M. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title_full | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title_fullStr | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title_full_unstemmed | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title_short | Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| title_sort | genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557485/ https://www.ncbi.nlm.nih.gov/pubmed/26237428 http://dx.doi.org/10.1038/ng.3373 |
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