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Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients

OBJECTIVE: In this study, we aimed to compare the cardiovascular risk factors that might be associated with inflammation, atherosclerosis and metabolic syndrome between hemodialysis and peritoneal dialysis patients. METHODS: Fifty hemodialysis and 50 peritoneal dialysis patients who had been receivi...

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Autores principales: Harmankaya, Ozlem, Akalin, Nilgul, Akay, Hatice, Okuturlar, Yildiz, Erturk, Kayhan, Kaptanogullari, Hakan, Kocoglu, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557587/
https://www.ncbi.nlm.nih.gov/pubmed/26375560
http://dx.doi.org/10.6061/clinics/2015(09)01
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author Harmankaya, Ozlem
Akalin, Nilgul
Akay, Hatice
Okuturlar, Yildiz
Erturk, Kayhan
Kaptanogullari, Hakan
Kocoglu, Hakan
author_facet Harmankaya, Ozlem
Akalin, Nilgul
Akay, Hatice
Okuturlar, Yildiz
Erturk, Kayhan
Kaptanogullari, Hakan
Kocoglu, Hakan
author_sort Harmankaya, Ozlem
collection PubMed
description OBJECTIVE: In this study, we aimed to compare the cardiovascular risk factors that might be associated with inflammation, atherosclerosis and metabolic syndrome between hemodialysis and peritoneal dialysis patients. METHODS: Fifty hemodialysis and 50 peritoneal dialysis patients who had been receiving dialysis therapy for at least one year were included in the study. Venous blood samples were taken after 12 hours of fasting, and serum glucose, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, C-reactive protein, fibrinogen and homocysteine levels were measured. The presence of atherosclerotic plaques in the carotid artery was evaluated by carotid Doppler ultrasound. These data were analyzed by Student's t test, the chi-square test and the Mann-Whitney U test, as appropriate. RESULTS: No difference was found between the hemodialysis (n=50) and peritoneal dialysis (n=50) patient groups regarding mean age, gender distribution, body mass index or dialysis duration (p=0.269, 0.683, 0.426, and 0.052, respectively). LDL-cholesterol, fibrinogen and homocysteine levels were significantly higher in peritoneal dialysis patients (p=0.006, 0.001, and 0.002, respectively). In patients with diabetes mellitus (n=17) who were undergoing renal replacement therapy, LDL-cholesterol and fibrinogen levels were significantly higher than in patients without diabetes mellitus who were undergoing renal replacement therapy (p=0.001 and 0.004, respectively). CONCLUSION: In our study, cardiovascular risk factors (especially LDL-cholesterol) were more frequent in peritoneal dialysis patients than in hemodialysis patients.
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spelling pubmed-45575872015-09-10 Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients Harmankaya, Ozlem Akalin, Nilgul Akay, Hatice Okuturlar, Yildiz Erturk, Kayhan Kaptanogullari, Hakan Kocoglu, Hakan Clinics (Sao Paulo) Clinical Science OBJECTIVE: In this study, we aimed to compare the cardiovascular risk factors that might be associated with inflammation, atherosclerosis and metabolic syndrome between hemodialysis and peritoneal dialysis patients. METHODS: Fifty hemodialysis and 50 peritoneal dialysis patients who had been receiving dialysis therapy for at least one year were included in the study. Venous blood samples were taken after 12 hours of fasting, and serum glucose, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol, C-reactive protein, fibrinogen and homocysteine levels were measured. The presence of atherosclerotic plaques in the carotid artery was evaluated by carotid Doppler ultrasound. These data were analyzed by Student's t test, the chi-square test and the Mann-Whitney U test, as appropriate. RESULTS: No difference was found between the hemodialysis (n=50) and peritoneal dialysis (n=50) patient groups regarding mean age, gender distribution, body mass index or dialysis duration (p=0.269, 0.683, 0.426, and 0.052, respectively). LDL-cholesterol, fibrinogen and homocysteine levels were significantly higher in peritoneal dialysis patients (p=0.006, 0.001, and 0.002, respectively). In patients with diabetes mellitus (n=17) who were undergoing renal replacement therapy, LDL-cholesterol and fibrinogen levels were significantly higher than in patients without diabetes mellitus who were undergoing renal replacement therapy (p=0.001 and 0.004, respectively). CONCLUSION: In our study, cardiovascular risk factors (especially LDL-cholesterol) were more frequent in peritoneal dialysis patients than in hemodialysis patients. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2015-09 2015-09 /pmc/articles/PMC4557587/ /pubmed/26375560 http://dx.doi.org/10.6061/clinics/2015(09)01 Text en Copyright © 2015 Clinics http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Science
Harmankaya, Ozlem
Akalin, Nilgul
Akay, Hatice
Okuturlar, Yildiz
Erturk, Kayhan
Kaptanogullari, Hakan
Kocoglu, Hakan
Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title_full Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title_fullStr Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title_full_unstemmed Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title_short Comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
title_sort comparison of risk factors for cardiovascular disease in hemodialysis and peritoneal dialysis patients
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557587/
https://www.ncbi.nlm.nih.gov/pubmed/26375560
http://dx.doi.org/10.6061/clinics/2015(09)01
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