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Nanoparticles as potential new generation broad spectrum antimicrobial agents
The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557602/ https://www.ncbi.nlm.nih.gov/pubmed/26329777 http://dx.doi.org/10.1186/s40199-015-0125-6 |
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author | Yah, Clarence S. Simate, Geoffrey S. |
author_facet | Yah, Clarence S. Simate, Geoffrey S. |
author_sort | Yah, Clarence S. |
collection | PubMed |
description | The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting treatment of intracellular pathogens. Therefore, the disease-causing-organisms tend to persist in these cells. However, the emergence of nanoparticle (NP) technology has come with the promising broad spectrum NP-antimicrobial agents due to their vast physiochemical and functionalization properties. In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens. Indeed, the perspective of developing potent NP-antimicrobial agents that carry multiple-functionality will revolutionize clinical medicine and play a significant role in alleviating disease burden. |
format | Online Article Text |
id | pubmed-4557602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45576022015-09-03 Nanoparticles as potential new generation broad spectrum antimicrobial agents Yah, Clarence S. Simate, Geoffrey S. Daru Review Article The rapid emergence of antimicrobial resistant strains to conventional antimicrobial agents has complicated and prolonged infection treatment and increased mortality risk globally. Furthermore, some of the conventional antimicrobial agents are unable to cross certain cell membranes thus, restricting treatment of intracellular pathogens. Therefore, the disease-causing-organisms tend to persist in these cells. However, the emergence of nanoparticle (NP) technology has come with the promising broad spectrum NP-antimicrobial agents due to their vast physiochemical and functionalization properties. In fact, NP-antimicrobial agents are able to unlock the restrictions experienced by conventional antimicrobial agents. This review discusses the status quo of NP-antimicrobial agents as potent broad spectrum antimicrobial agents, sterilization and wound healing agents, and sustained inhibitors of intracellular pathogens. Indeed, the perspective of developing potent NP-antimicrobial agents that carry multiple-functionality will revolutionize clinical medicine and play a significant role in alleviating disease burden. BioMed Central 2015-09-02 /pmc/articles/PMC4557602/ /pubmed/26329777 http://dx.doi.org/10.1186/s40199-015-0125-6 Text en © Yah and Simate. 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Article Yah, Clarence S. Simate, Geoffrey S. Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title | Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title_full | Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title_fullStr | Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title_full_unstemmed | Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title_short | Nanoparticles as potential new generation broad spectrum antimicrobial agents |
title_sort | nanoparticles as potential new generation broad spectrum antimicrobial agents |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557602/ https://www.ncbi.nlm.nih.gov/pubmed/26329777 http://dx.doi.org/10.1186/s40199-015-0125-6 |
work_keys_str_mv | AT yahclarences nanoparticlesaspotentialnewgenerationbroadspectrumantimicrobialagents AT simategeoffreys nanoparticlesaspotentialnewgenerationbroadspectrumantimicrobialagents |