Cargando…

A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

CHO cell culture high productivity relies on optimized culture medium management under fed-batch or perfused chemostat strategies enabling high cell densities. In this work, a dynamic metabolic model for CHO cells was further developed, calibrated and challenged using datasets obtained under four di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Robitaille, Julien, Chen, Jingkui, Jolicoeur, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558054/ https://www.ncbi.nlm.nih.gov/pubmed/26331955 http://dx.doi.org/10.1371/journal.pone.0136815

Ejemplares similares

Selection of chemically defined media for CHO cell fed-batch culture processes
por: Pan, Xiao, et al.
Publicado: (2016)

Progress in fed-batch culture for recombinant protein production in CHO cells
por: Xu, Wen-Jing, et al.
Publicado: (2023)

Model-Based Optimization of a Fed-Batch Bioreactor for mAb Production Using a Hybridoma Cell Culture
por: Maria, Gheorghe
Publicado: (2020)

Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
por: Pan, Xiao, et al.
Publicado: (2017)

Segmented linear modeling of CHO fed‐batch culture and its application to large scale production
por: Ben Yahia, Bassem, et al.
Publicado: (2016)

Profiling of glycosylation gene expression in CHO fed-batch cultures in response to glycosylation-enhancing medium components
por: Boniface, Ryan, et al.
Publicado: (2013)

Model-based intensification of CHO cell cultures: One-step strategy from fed-batch to perfusion
por: Richelle, Anne, et al.
Publicado: (2022)

Rapid intensification of an established CHO cell fed‐batch process
por: Schulze, Markus, et al.
Publicado: (2021)

Life‐cycle and cost of goods assessment of fed‐batch and perfusion‐based manufacturing processes for mAbs
por: Bunnak, Phumthep, et al.
Publicado: (2016)

Glycolysis and the regulation of glucose transport in Lactococcus lactis spp. lactis in batch and fed-batch culture
por: Papagianni, Maria, et al.
Publicado: (2007)

Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture
por: Shang, Menglin, et al.
Publicado: (2021)

Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
por: Chitwood, Dylan G., et al.
Publicado: (2021)

Chemically modified cysteine in CHO fed-batch processes and impact on the specific productivity
por: Hecklau, Caroline, et al.
Publicado: (2015)

Lipid production in batch and fed-batch cultures of Rhodosporidium toruloides from 5 and 6 carbon carbohydrates
por: Wiebe, Marilyn G, et al.
Publicado: (2012)

Medium and feed optimization for fed-batch production of a monoclonal antibody in CHO cells
por: Kochanowski, Nadine, et al.
Publicado: (2011)

Process development and optimization of fed-batch production processes for therapeutic proteins by CHO cells
por: Clincke, Marie-Françoise, et al.
Publicado: (2013)

Efficient biosynthesis of exopolysaccharide in Candida glabrata by a fed-batch culture
por: Xu, Sha, et al.
Publicado: (2022)

The successful transfer of a modern CHO fed-batch process to different single-use bioreactors
por: Ruhl, Sebastian, et al.
Publicado: (2013)

Estimating Extrinsic Dyes for Fluorometric Online Monitoring of Antibody Aggregation in CHO Fed-Batch Cultivations
por: Schwab, Karen, et al.
Publicado: (2017)

A buffered media system for yeast batch culture growth
por: Prins, Rianne C., et al.
Publicado: (2021)

Identifying conditions for inducible protein production in E. coli: combining a fed-batch and multiple induction approach
por: Aucoin, Marc G, et al.
Publicado: (2006)

Production of Carotenoids and Phospholipids by Thraustochytrium sp. in Batch and Repeated-Batch Culture
por: Leyton, Allison, et al.
Publicado: (2022)

Protein folding and glycosylation process are influenced by mild hypothermia in batch culture and by specific growth rate in continuous cultures of CHO cells producing rht-PA
por: Vergara, Mauricio, et al.
Publicado: (2013)

Strategies for adaptation of mAb-producing CHO cells to serum-free medium
por: Costa, A Rita, et al.
Publicado: (2011)

How to assess chemically defined media and feeds from 9 suppliers on CHO cells producing mAb
por: Polès-Lahille, Aurore, et al.
Publicado: (2013)

Achieving pH control in microalgal cultures through fed-batch addition of stoichiometrically-balanced growth media
por: Scherholz, Megerle L, et al.
Publicado: (2013)

Applications of off-gas mass spectrometry in fed-batch mammalian cell culture
por: Goh, Hai-Yuan, et al.
Publicado: (2019)

Investigation of the robustness of Cupriavidus necator engineered strains during fed-batch cultures
por: Boy, Catherine, et al.
Publicado: (2021)

Optimization of glutathione production in batch and fed-batch cultures by the wild-type and recombinant strains of the methylotrophic yeast Hansenula polymorpha DL-1
por: Ubiyvovk, Vira M, et al.
Publicado: (2011)

Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
por: Mahé, Amélie, et al.
Publicado: (2021)

Glucose transport engineering allows mimicking fed-batch performance in batch mode and selection of superior producer strains
por: Velazquez, Daniela, et al.
Publicado: (2022)

Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform
por: Ghorbaniaghdam, Atefeh, et al.
Publicado: (2014)

Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology
por: Stepper, Lisa, et al.
Publicado: (2020)

Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors
por: Metze, S., et al.
Publicado: (2019)

Temperature limited fed-batch technique for control of proteolysis in Pichia pastoris bioreactor cultures
por: Jahic, Mehmedalija, et al.
Publicado: (2003)

Transcriptomic analysis reveals mode of action of butyric acid supplementation in an intensified CHO cell fed‐batch process
por: Schulze, Markus, et al.
Publicado: (2022)

Batch culture and repeated-batch culture of Cunninghamella bainieri 2A1 for lipid production as a comparative study
por: Dashti, Marjan Ganjali, et al.
Publicado: (2016)

Carotenoid Production by Rhodotorula mucilaginosa in Batch and Fed-Batch Fermentation Using Agroindustrial Byproducts
por: Dias Rodrigues, Tábita Veiga, et al.
Publicado: (2019)

Media optimization for CHO fed-batch processes using a DoE approach in automated high-throughput single use ambr15 bioreactors
por: Grimm, Christophe, et al.
Publicado: (2015)

Novel strategy for a high-yielding mAb-producing CHO strain (overexpression of non-coding RNA enhanced proliferation and improved mAb yield)
por: Tabuchi, Hisahiro
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_504e3j6gocosg2i4avslndo9n4