Cargando…
Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline
In searching for small-molecule compounds that inhibit proliferation and survival of diffuse large B-cell lymphoma (DLBCL) cells and may, therefore, be exploited as potential therapeutic agents for this disease, we identified the commonly used and well-tolerated antibiotic doxycycline as a strong ca...
Autores principales: | Pulvino, Mary, Chen, Luojing, Oleksyn, David, Li, Jing, Compitello, George, Rossi, Randy, Spence, Stephen, Balakrishnan, Vijaya, Jordan, Craig, Poligone, Brian, Casulo, Carla, Burack, Richard, Shapiro, Joel L., Bernstein, Steven, Friedberg, Jonathan W., Deshaies, Raymond J., Land, Hartmut, Zhao, Jiyong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558116/ https://www.ncbi.nlm.nih.gov/pubmed/26142707 |
Ejemplares similares
-
Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
por: Mosadeghi, Ruzbeh, et al.
Publicado: (2016) -
Role of the COP9 Signalosome (CSN) in Cardiovascular Diseases
por: Milic, Jelena, et al.
Publicado: (2019) -
Structural and Biochemical Characterization of the Cop9 Signalosome CSN5/CSN6 Heterodimer
por: Birol, Melissa, et al.
Publicado: (2014) -
Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
por: Emberley, Ethan D., et al.
Publicado: (2012) -
The COP9 signalosome subunit 6 (CSN6): a potential oncogene
por: Zhang, Shang-Nuan, et al.
Publicado: (2013)