Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

The T-cell lymphoproliferative neoplasms (T-LPN) are characterized by a poor clinical outcome. Current therapeutics are mostly non-selective and may induce harmful side effects. It has been reported that NOTCH1 activation mutations frequently associate T-LPN. Because anti-Notch1 based therapies such...

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Detalles Bibliográficos
Autores principales: Yang, Lujun, Zhang, Shuangfeng, George, Suraj Konnath, Teng, Rong, You, Xuefen, Xu, Mengqi, Liu, Hong, Sun, Xiaoping, Amin, Hesham M., Shi, Wenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558128/
https://www.ncbi.nlm.nih.gov/pubmed/25879451

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