Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet unrealized, target for anti-tumor intervention. Here we identify a small molecule, homoharringtonine (HHT), that antagonizes p-eIF4E function and er...

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Detalles Bibliográficos
Autores principales: Gu, Ying, Zhou, Hong, Gan, Yichao, Zhang, Jiawei, Chen, Jianghua, Gan, Xiaoxian, Li, Hongzhi, Zheng, Weiwei, Meng, Zhipeng, Ma, Xiaoxiao, Wang, Xichun, Xu, Xiaohua, Xu, Ganyu, Lu, Xiaoya, Liang, Yun, Zhang, Xuzhao, Lu, Xinliang, Huang, Wendong, Xu, Rongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558139/
https://www.ncbi.nlm.nih.gov/pubmed/25915158

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