The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

The response of BRAF-mutant melanoma patients to BRAF inhibitors is dramatically impaired by secondary resistances and rapid relapse. So far, the molecular mechanisms driving these resistances are not completely understood. Here, we show that, in BRAF-mutant melanoma cells, inhibition of BRAF or its...

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Detalles Bibliográficos
Autores principales: Delmas, Audrey, Cherier, Julia, Pohorecka, Magdalena, Medale-Giamarchi, Claire, Meyer, Nicolas, Casanova, Anne, Sordet, Olivier, Lamant, Laurence, Savina, Ariel, Pradines, Anne, Favre, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558149/
https://www.ncbi.nlm.nih.gov/pubmed/26098773

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