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Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population

Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorp...

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Autores principales: Yang, Chao, Tang, Ran, Ma, Xiang, Wang, Younan, Luo, Dakui, Xu, Zekuan, Zhu, Yi, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558153/
https://www.ncbi.nlm.nih.gov/pubmed/25944697
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author Yang, Chao
Tang, Ran
Ma, Xiang
Wang, Younan
Luo, Dakui
Xu, Zekuan
Zhu, Yi
Yang, Li
author_facet Yang, Chao
Tang, Ran
Ma, Xiang
Wang, Younan
Luo, Dakui
Xu, Zekuan
Zhu, Yi
Yang, Li
author_sort Yang, Chao
collection PubMed
description Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs) (rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. Carriers of variant rs217727T and rs2839698T alleles showed increased GC risk (P = 0.008 and 0.011, respectively). Compared with the common genotype, CT + TT rs217727 and CT + TT rs2839698 genotypes were associated with significantly increased GC risk (P = 0.040, adjusted odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.01–1.71; P = 0.033, adjusted OR = 1.31, 95% CI = 1.02–1.69, respectively). Further stratified analyses revealed that the association between GC risk and variant genotypes of rs217727 was more profound in younger individuals (≤59 years) and non-smokers, while the association between risk and the rare rs2839698 genotype persisted in men and rural subjects. rs2839698 CT and TT genotypes were also associated with higher serum H19 mRNA levels compared with the CC genotype. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC.
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spelling pubmed-45581532015-09-09 Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population Yang, Chao Tang, Ran Ma, Xiang Wang, Younan Luo, Dakui Xu, Zekuan Zhu, Yi Yang, Li Oncotarget Research Paper Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs) (rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. Carriers of variant rs217727T and rs2839698T alleles showed increased GC risk (P = 0.008 and 0.011, respectively). Compared with the common genotype, CT + TT rs217727 and CT + TT rs2839698 genotypes were associated with significantly increased GC risk (P = 0.040, adjusted odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.01–1.71; P = 0.033, adjusted OR = 1.31, 95% CI = 1.02–1.69, respectively). Further stratified analyses revealed that the association between GC risk and variant genotypes of rs217727 was more profound in younger individuals (≤59 years) and non-smokers, while the association between risk and the rare rs2839698 genotype persisted in men and rural subjects. rs2839698 CT and TT genotypes were also associated with higher serum H19 mRNA levels compared with the CC genotype. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC. Impact Journals LLC 2015-04-15 /pmc/articles/PMC4558153/ /pubmed/25944697 Text en Copyright: © 2015 Yang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yang, Chao
Tang, Ran
Ma, Xiang
Wang, Younan
Luo, Dakui
Xu, Zekuan
Zhu, Yi
Yang, Li
Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title_full Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title_fullStr Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title_full_unstemmed Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title_short Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
title_sort tag snps in long non-coding rna h19 contribute to susceptibility to gastric cancer in the chinese han population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558153/
https://www.ncbi.nlm.nih.gov/pubmed/25944697
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