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Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558153/ https://www.ncbi.nlm.nih.gov/pubmed/25944697 |
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author | Yang, Chao Tang, Ran Ma, Xiang Wang, Younan Luo, Dakui Xu, Zekuan Zhu, Yi Yang, Li |
author_facet | Yang, Chao Tang, Ran Ma, Xiang Wang, Younan Luo, Dakui Xu, Zekuan Zhu, Yi Yang, Li |
author_sort | Yang, Chao |
collection | PubMed |
description | Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs) (rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. Carriers of variant rs217727T and rs2839698T alleles showed increased GC risk (P = 0.008 and 0.011, respectively). Compared with the common genotype, CT + TT rs217727 and CT + TT rs2839698 genotypes were associated with significantly increased GC risk (P = 0.040, adjusted odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.01–1.71; P = 0.033, adjusted OR = 1.31, 95% CI = 1.02–1.69, respectively). Further stratified analyses revealed that the association between GC risk and variant genotypes of rs217727 was more profound in younger individuals (≤59 years) and non-smokers, while the association between risk and the rare rs2839698 genotype persisted in men and rural subjects. rs2839698 CT and TT genotypes were also associated with higher serum H19 mRNA levels compared with the CC genotype. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC. |
format | Online Article Text |
id | pubmed-4558153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-45581532015-09-09 Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population Yang, Chao Tang, Ran Ma, Xiang Wang, Younan Luo, Dakui Xu, Zekuan Zhu, Yi Yang, Li Oncotarget Research Paper Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single nucleotide polymorphisms (SNPs) (rs217727 C > T, rs2839698 C > T, rs3741216 A > T, rs3741219 T > C) in 500 GC patients and 500 healthy controls. Carriers of variant rs217727T and rs2839698T alleles showed increased GC risk (P = 0.008 and 0.011, respectively). Compared with the common genotype, CT + TT rs217727 and CT + TT rs2839698 genotypes were associated with significantly increased GC risk (P = 0.040, adjusted odds ratio [OR] = 1.32, 95% confidence interval [CI] = 1.01–1.71; P = 0.033, adjusted OR = 1.31, 95% CI = 1.02–1.69, respectively). Further stratified analyses revealed that the association between GC risk and variant genotypes of rs217727 was more profound in younger individuals (≤59 years) and non-smokers, while the association between risk and the rare rs2839698 genotype persisted in men and rural subjects. rs2839698 CT and TT genotypes were also associated with higher serum H19 mRNA levels compared with the CC genotype. These findings suggest that lncRNA H19 SNPs may contribute to susceptibility to GC. Impact Journals LLC 2015-04-15 /pmc/articles/PMC4558153/ /pubmed/25944697 Text en Copyright: © 2015 Yang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yang, Chao Tang, Ran Ma, Xiang Wang, Younan Luo, Dakui Xu, Zekuan Zhu, Yi Yang, Li Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title | Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title_full | Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title_fullStr | Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title_full_unstemmed | Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title_short | Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population |
title_sort | tag snps in long non-coding rna h19 contribute to susceptibility to gastric cancer in the chinese han population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558153/ https://www.ncbi.nlm.nih.gov/pubmed/25944697 |
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