Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo

We observed a co-upregulation of the insulin-like growth factor receptor (IGF-1R)/AKT/mammalian target of rapamycin (mTOR) [InAT] axis and the mevalonate-isoprenoid biosynthesis (MIB) pathways in colorectal cancer stem cells (CSCs) in an unbiased approach. Hence, we hypothesized that the InAT axis m...

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Detalles Bibliográficos
Autores principales: Sharon, Chetna, Baranwal, Somesh, Patel, Nirmita J., Rodriguez-Agudo, Daniel, Pandak, William M., Majumdar, Adhip PN, Krystal, Geoffrey, Patel, Bhaumik B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558155/
https://www.ncbi.nlm.nih.gov/pubmed/25895029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558155/
https://www.ncbi.nlm.nih.gov/pubmed/25895029

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