Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors

Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of childhood. Re-analyses of mRNA profiling data fr...

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Detalles Bibliográficos
Autores principales: Schwermer, Melanie, Lee, Sangkyun, Köster, Johannes, van Maerken, Tom, Stephan, Harald, Eggert, Angelika, Morik, Katharina, Schulte, Johannes H., Schramm, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558161/
https://www.ncbi.nlm.nih.gov/pubmed/26029996

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