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A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model

In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and it...

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Autores principales: Hwang, Jin Ho, Park, Hong Suk, Seo, Soowon, Choo, In Wook, Do, Young Soo, Choo, Sung Wook, Shin, Sung Wook, Park, Kwang Bo, Cho, Sung Ki, Hyun, Dongho, Lim, Sooyoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558424/
https://www.ncbi.nlm.nih.gov/pubmed/26366422
http://dx.doi.org/10.1155/2015/974537
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author Hwang, Jin Ho
Park, Hong Suk
Seo, Soowon
Choo, In Wook
Do, Young Soo
Choo, Sung Wook
Shin, Sung Wook
Park, Kwang Bo
Cho, Sung Ki
Hyun, Dongho
Lim, Sooyoun
author_facet Hwang, Jin Ho
Park, Hong Suk
Seo, Soowon
Choo, In Wook
Do, Young Soo
Choo, Sung Wook
Shin, Sung Wook
Park, Kwang Bo
Cho, Sung Ki
Hyun, Dongho
Lim, Sooyoun
author_sort Hwang, Jin Ho
collection PubMed
description In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and its usefulness in experimental intervention in animal model. The mean size of microbubble of foam contrast was 13.8 ± 3.6 µm. The viscosity was 201.0 ± 0.624 cP (centipoise) and the specific gravity was 0.616. The foam decayed slowly and it had 97.5 minutes of half-life. In terms of the sustainability in a slow flow environment, foam contrast washed out much more slowly than a conventional contrast. In experimental colonic stent placement, foam contrast revealed significantly better results than conventional contrast in procedure time, total amount of contrast usage, and the number of injections (p < 0.05). Our foam contrast has high viscosity and low specific gravity and maintains foam state for a sufficient time. Foam contrast with these properties was useful in experimental intervention in animal model. We anticipate that foam contrast may be applied to various kinds of interventional procedures.
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spelling pubmed-45584242015-09-13 A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model Hwang, Jin Ho Park, Hong Suk Seo, Soowon Choo, In Wook Do, Young Soo Choo, Sung Wook Shin, Sung Wook Park, Kwang Bo Cho, Sung Ki Hyun, Dongho Lim, Sooyoun Biomed Res Int Research Article In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and its usefulness in experimental intervention in animal model. The mean size of microbubble of foam contrast was 13.8 ± 3.6 µm. The viscosity was 201.0 ± 0.624 cP (centipoise) and the specific gravity was 0.616. The foam decayed slowly and it had 97.5 minutes of half-life. In terms of the sustainability in a slow flow environment, foam contrast washed out much more slowly than a conventional contrast. In experimental colonic stent placement, foam contrast revealed significantly better results than conventional contrast in procedure time, total amount of contrast usage, and the number of injections (p < 0.05). Our foam contrast has high viscosity and low specific gravity and maintains foam state for a sufficient time. Foam contrast with these properties was useful in experimental intervention in animal model. We anticipate that foam contrast may be applied to various kinds of interventional procedures. Hindawi Publishing Corporation 2015 2015-08-20 /pmc/articles/PMC4558424/ /pubmed/26366422 http://dx.doi.org/10.1155/2015/974537 Text en Copyright © 2015 Jin Ho Hwang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hwang, Jin Ho
Park, Hong Suk
Seo, Soowon
Choo, In Wook
Do, Young Soo
Choo, Sung Wook
Shin, Sung Wook
Park, Kwang Bo
Cho, Sung Ki
Hyun, Dongho
Lim, Sooyoun
A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title_full A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title_fullStr A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title_full_unstemmed A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title_short A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
title_sort novel foam contrast agent suitable for fluoroscopic interventional procedure: comparative study of physical properties and experimental intervention in animal model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558424/
https://www.ncbi.nlm.nih.gov/pubmed/26366422
http://dx.doi.org/10.1155/2015/974537
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