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A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model
In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and it...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558424/ https://www.ncbi.nlm.nih.gov/pubmed/26366422 http://dx.doi.org/10.1155/2015/974537 |
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author | Hwang, Jin Ho Park, Hong Suk Seo, Soowon Choo, In Wook Do, Young Soo Choo, Sung Wook Shin, Sung Wook Park, Kwang Bo Cho, Sung Ki Hyun, Dongho Lim, Sooyoun |
author_facet | Hwang, Jin Ho Park, Hong Suk Seo, Soowon Choo, In Wook Do, Young Soo Choo, Sung Wook Shin, Sung Wook Park, Kwang Bo Cho, Sung Ki Hyun, Dongho Lim, Sooyoun |
author_sort | Hwang, Jin Ho |
collection | PubMed |
description | In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and its usefulness in experimental intervention in animal model. The mean size of microbubble of foam contrast was 13.8 ± 3.6 µm. The viscosity was 201.0 ± 0.624 cP (centipoise) and the specific gravity was 0.616. The foam decayed slowly and it had 97.5 minutes of half-life. In terms of the sustainability in a slow flow environment, foam contrast washed out much more slowly than a conventional contrast. In experimental colonic stent placement, foam contrast revealed significantly better results than conventional contrast in procedure time, total amount of contrast usage, and the number of injections (p < 0.05). Our foam contrast has high viscosity and low specific gravity and maintains foam state for a sufficient time. Foam contrast with these properties was useful in experimental intervention in animal model. We anticipate that foam contrast may be applied to various kinds of interventional procedures. |
format | Online Article Text |
id | pubmed-4558424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-45584242015-09-13 A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model Hwang, Jin Ho Park, Hong Suk Seo, Soowon Choo, In Wook Do, Young Soo Choo, Sung Wook Shin, Sung Wook Park, Kwang Bo Cho, Sung Ki Hyun, Dongho Lim, Sooyoun Biomed Res Int Research Article In fluoroscopic contrast study for interventional procedure, liquid contrast agent may be diluted in body fluid, losing its contrast effect. We developed a novel contrast agent of “foam state” to maintain contrast effect for enough time and performed a comparative study of physical properties and its usefulness in experimental intervention in animal model. The mean size of microbubble of foam contrast was 13.8 ± 3.6 µm. The viscosity was 201.0 ± 0.624 cP (centipoise) and the specific gravity was 0.616. The foam decayed slowly and it had 97.5 minutes of half-life. In terms of the sustainability in a slow flow environment, foam contrast washed out much more slowly than a conventional contrast. In experimental colonic stent placement, foam contrast revealed significantly better results than conventional contrast in procedure time, total amount of contrast usage, and the number of injections (p < 0.05). Our foam contrast has high viscosity and low specific gravity and maintains foam state for a sufficient time. Foam contrast with these properties was useful in experimental intervention in animal model. We anticipate that foam contrast may be applied to various kinds of interventional procedures. Hindawi Publishing Corporation 2015 2015-08-20 /pmc/articles/PMC4558424/ /pubmed/26366422 http://dx.doi.org/10.1155/2015/974537 Text en Copyright © 2015 Jin Ho Hwang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hwang, Jin Ho Park, Hong Suk Seo, Soowon Choo, In Wook Do, Young Soo Choo, Sung Wook Shin, Sung Wook Park, Kwang Bo Cho, Sung Ki Hyun, Dongho Lim, Sooyoun A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title | A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title_full | A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title_fullStr | A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title_full_unstemmed | A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title_short | A Novel Foam Contrast Agent Suitable for Fluoroscopic Interventional Procedure: Comparative Study of Physical Properties and Experimental Intervention in Animal Model |
title_sort | novel foam contrast agent suitable for fluoroscopic interventional procedure: comparative study of physical properties and experimental intervention in animal model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558424/ https://www.ncbi.nlm.nih.gov/pubmed/26366422 http://dx.doi.org/10.1155/2015/974537 |
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