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p53- and p73-independent activation of TIGAR expression in vivo

TIGAR (TP53-induced glycolysis and apoptosis regulator) functions as a fructose-2,6-bisphosphatase and its expression results in a dampening of the glycolytic pathway, while increasing antioxidant capacity by increasing NADPH and GSH levels. In addition to being a p53 target, p53-independent express...

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Detalles Bibliográficos
Autores principales:	Lee, P, Hock, A K, Vousden, K H, Cheung, E C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558498/ https://www.ncbi.nlm.nih.gov/pubmed/26247727 http://dx.doi.org/10.1038/cddis.2015.205

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