NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis

Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase. We hypothesize that inhibiting DUSP26 will result in decreased...

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Detalles Bibliográficos
Autores principales: Shi, Y, Ma, I T, Patel, R H, Shang, X, Chen, Z, Zhao, Y, Cheng, J, Fan, Y, Rojas, Y, Barbieri, E, Yu, Y, Jin, J, Kim, E S, Shohet, J M, Vasudevan, S A, Yang, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558500/
https://www.ncbi.nlm.nih.gov/pubmed/26247726
http://dx.doi.org/10.1038/cddis.2015.207

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