Scaffolding protein Homer1a protects against NMDA-induced neuronal injury

Excessive N-methyl-D-aspartate receptor (NMDAR) activation and the resulting activation of neuronal nitric oxide synthase (nNOS) cause neuronal injury. Homer1b/c facilitates NMDAR-PSD95-nNOS complex interactions, and Homer1a is a negative competitor of Homer1b/c. We report that Homer1a was both upre...

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Detalles Bibliográficos
Autores principales: Wang, Y, Rao, W, Zhang, C, Liu, M-d, Han, F, Yao, L-b, Han, H, Luo, P, Su, N, Fei, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558508/
https://www.ncbi.nlm.nih.gov/pubmed/26247728
http://dx.doi.org/10.1038/cddis.2015.216

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