Cargando…

α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway

α-Solanine is a glycoalkaloid found in species of the nightshade family including potato. It was primarily reported to have toxic effects in humans. However, there is a growing body of literature demonstrating in vitro and in vivo anticancer activity of α-solanine. Most of these studies have shown a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hasanain, M, Bhattacharjee, A, Pandey, P, Ashraf, R, Singh, N, Sharma, S, Vishwakarma, A L, Datta, D, Mitra, K, Sarkar, J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558510/ https://www.ncbi.nlm.nih.gov/pubmed/26313911 http://dx.doi.org/10.1038/cddis.2015.219

Ejemplares similares

Ormeloxifene-induced unfolded protein response contributes to autophagy-associated apoptosis via disruption of Akt/mTOR and activation of JNK
por: Bhattacharjee, Arindam, et al.
Publicado: (2018)

Depletion of Luminal Pyridine Nucleotides in the Endoplasmic Reticulum Activates Autophagy with the Involvement of mTOR Pathway
por: Kapuy, Orsolya, et al.
Publicado: (2013)

GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy
por: Holczer, Marianna, et al.
Publicado: (2016)

Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress
por: Zhou, Yong, et al.
Publicado: (2014)

Inhibition of p21 activates Akt kinase to trigger ROS-induced autophagy and impacts on tumor growth rate
por: Maheshwari, Mayank, et al.
Publicado: (2022)

mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4(+) T Cell Apoptosis Mediated by ROS in Septic Immunosuppression
por: Wang, Hao, et al.
Publicado: (2022)

Algae Undaria pinnatifida Protects Hypothalamic Neurons against Endoplasmic Reticulum Stress through Akt/mTOR Signaling
por: Kim, Jongwan, et al.
Publicado: (2015)

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Chrysin induces autophagy through the inactivation of the ROS-mediated Akt/mTOR signaling pathway in endometrial cancer
por: He, Yu, et al.
Publicado: (2021)

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway
por: Shao, Shali, et al.
Publicado: (2022)

mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study
por: Kapuy, Orsolya, et al.
Publicado: (2014)

Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
por: Wang, Yu-Ming, et al.
Publicado: (2021)

Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling
por: Pang, Jiaojiao, et al.
Publicado: (2016)

Endoplasmic reticulum stress induces autophagy and apoptosis while inhibiting proliferation and drug resistance in multiple myeloma through the PI3K/Akt/mTOR signaling pathway
por: Fu, Yun-Feng, et al.
Publicado: (2017)

Correction to: Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Fluorochloridone induces autophagy in TM4 Sertoli cells: involvement of ROS-mediated AKT-mTOR signaling pathway
por: Ni, Zhijing, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress and Associated ROS
por: Zeeshan, Hafiz Maher Ali, et al.
Publicado: (2016)

α-Solanine Causes Cellular Dysfunction of Human Trophoblast Cells via Apoptosis and Autophagy
por: Chen, Zhilong, et al.
Publicado: (2021)

Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response
por: Camacho, Alberto, et al.
Publicado: (2012)

mTOR controls endoplasmic reticulum–Golgi apparatus trafficking of VSVg in specific cell types
por: Koscielny, Alicja, et al.
Publicado: (2021)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway
por: Fang, Shaohong, et al.
Publicado: (2021)

Ca(2+)-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling
por: Yu, Zhihua, et al.
Publicado: (2018)

ROS and Endoplasmic Reticulum Stress in Pulmonary Disease
por: Cui, Xiangning, et al.
Publicado: (2022)

Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway
por: Yu, Xin-Shuang, et al.
Publicado: (2016)

Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress
por: Holczer, Marianna, et al.
Publicado: (2018)

Retraction: Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway
por: Yu, Xin-Shuang, et al.
Publicado: (2019)

ROS, Klotho and mTOR in cardiorenal aging
por: Daneshgar, Nastaran, et al.
Publicado: (2020)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells
por: Zhao, Zhuyun, et al.
Publicado: (2021)

Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells
por: Goan, Yih-Gang, et al.
Publicado: (2019)

Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K/Akt/mTOR Signaling Pathway
por: Lee, Hyun-Su, et al.
Publicado: (2021)

An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response
por: Chang, Jae-Woong, et al.
Publicado: (2018)

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis
por: Karali, Evdoxia, et al.
Publicado: (2014)

mTOR pathway mediates endoplasmic reticulum stress-induced CD4(+) T cell apoptosis in septic mice
por: Bai, Guangxu, et al.
Publicado: (2022)

Low-frequency ultrasound enhances chemotherapy sensitivity and induces autophagy in PTX-resistant PC-3 cells via the endoplasmic reticulum stress-mediated PI3K/Akt/mTOR signaling pathway
por: Wu, Yuqi, et al.
Publicado: (2018)

Evaluation of antifungal and cytotoxic activity of trans-Chalcone and α-Solanine
por: Komoto, Tatiana Takahasi, et al.
Publicado: (2014)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Streptococcus pneumoniae Induces Autophagy through the Inhibition of the PI3K-I/Akt/mTOR Pathway and ROS Hypergeneration in A549 Cells
por: Li, Pu, et al.
Publicado: (2015)

SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling
por: Li, Fei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f8cp23up9sqt3l3n2ga24sqgkf