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Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation

The origin of rhabdomyosarcoma (RMS) remains controversial. However, specific microRNAs (miRNAs) are downregulated in RMS and it is possible that re-expression of these miRNAs may lead to differentiation. Transforming growth factor-β1 (TGF-β1) is known to block differentiation of RMS. We therefore a...

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Detalles Bibliográficos
Autores principales:	Sun, M, Huang, F, Yu, D, Zhang, Y, Xu, H, Zhang, L, Li, L, Dong, L, Guo, L, Wang, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558514/ https://www.ncbi.nlm.nih.gov/pubmed/26291313 http://dx.doi.org/10.1038/cddis.2015.225

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