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Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge

Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the prim...

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Autores principales: Ji, Suk, Choi, Youngnim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558535/
https://www.ncbi.nlm.nih.gov/pubmed/26389079
http://dx.doi.org/10.3389/fcimb.2015.00065
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author Ji, Suk
Choi, Youngnim
author_facet Ji, Suk
Choi, Youngnim
author_sort Ji, Suk
collection PubMed
description Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. However, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progresses to the point of no return. Furthermore, the current diagnosis of periodontitis depends on time-consuming clinical measurements. Therefore, there is an unmet need for near-patient testing to diagnose periodontitis. Saliva is an optimal biological fluid to serve as a near-patient diagnostic tool for periodontitis. Recent developments in point-of-care (POC) testing indicate that a diagnostic test for periodontitis using saliva is now technically feasible. A number of promising salivary biomarkers associated with periodontitis have been reported. A panel of optimal biomarkers must be carefully selected based on the pathogenesis of periodontitis. The biggest hurdle for the POC diagnosis of periodontitis using saliva may be the process of validation in a large, diverse patient population. Therefore, we propose the organization of an International Consortium for Biomarkers of Periodontitis, which will gather efforts to identify, select, and validate salivary biomarkers for the diagnosis of periodontitis.
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spelling pubmed-45585352015-09-18 Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge Ji, Suk Choi, Youngnim Front Cell Infect Microbiol Microbiology Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. However, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progresses to the point of no return. Furthermore, the current diagnosis of periodontitis depends on time-consuming clinical measurements. Therefore, there is an unmet need for near-patient testing to diagnose periodontitis. Saliva is an optimal biological fluid to serve as a near-patient diagnostic tool for periodontitis. Recent developments in point-of-care (POC) testing indicate that a diagnostic test for periodontitis using saliva is now technically feasible. A number of promising salivary biomarkers associated with periodontitis have been reported. A panel of optimal biomarkers must be carefully selected based on the pathogenesis of periodontitis. The biggest hurdle for the POC diagnosis of periodontitis using saliva may be the process of validation in a large, diverse patient population. Therefore, we propose the organization of an International Consortium for Biomarkers of Periodontitis, which will gather efforts to identify, select, and validate salivary biomarkers for the diagnosis of periodontitis. Frontiers Media S.A. 2015-09-03 /pmc/articles/PMC4558535/ /pubmed/26389079 http://dx.doi.org/10.3389/fcimb.2015.00065 Text en Copyright © 2015 Ji and Choi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ji, Suk
Choi, Youngnim
Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title_full Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title_fullStr Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title_full_unstemmed Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title_short Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
title_sort point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558535/
https://www.ncbi.nlm.nih.gov/pubmed/26389079
http://dx.doi.org/10.3389/fcimb.2015.00065
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