CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X

Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in host cells as episomal covalently closed circular DNA (cccDNA) and, to a lesser extent, as chromosomally integrated sequen...

Descripción completa

Detalles Bibliográficos
Autores principales: Karimova, Madina, Beschorner, Niklas, Dammermann, Werner, Chemnitz, Jan, Indenbirken, Daniela, Bockmann, Jan-Hendrik, Grundhoff, Adam, Lüth, Stefan, Buchholz, Frank, Wiesch, Julian Schulze zur, Hauber, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558539/
https://www.ncbi.nlm.nih.gov/pubmed/26334116
http://dx.doi.org/10.1038/srep13734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558539/
https://www.ncbi.nlm.nih.gov/pubmed/26334116
http://dx.doi.org/10.1038/srep13734

Ejemplares similares