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CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X

Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV eradication would require inactivation of the viral genome, which primarily persists in host cells as episomal covalently closed circular DNA (cccDNA) and, to a lesser extent, as chromosomally integrated sequen...

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Detalles Bibliográficos
Autores principales:	Karimova, Madina, Beschorner, Niklas, Dammermann, Werner, Chemnitz, Jan, Indenbirken, Daniela, Bockmann, Jan-Hendrik, Grundhoff, Adam, Lüth, Stefan, Buchholz, Frank, Wiesch, Julian Schulze zur, Hauber, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558539/ https://www.ncbi.nlm.nih.gov/pubmed/26334116 http://dx.doi.org/10.1038/srep13734

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