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Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling

Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as...

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Autores principales: Neal, Scott J, Takeishi, Asuka, O'Donnell, Michael P, Park, JiSoo, Hong, Myeongjin, Butcher, Rebecca A, Kim, Kyuhyung, Sengupta, Piali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558564/
https://www.ncbi.nlm.nih.gov/pubmed/26335407
http://dx.doi.org/10.7554/eLife.10110
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author Neal, Scott J
Takeishi, Asuka
O'Donnell, Michael P
Park, JiSoo
Hong, Myeongjin
Butcher, Rebecca A
Kim, Kyuhyung
Sengupta, Piali
author_facet Neal, Scott J
Takeishi, Asuka
O'Donnell, Michael P
Park, JiSoo
Hong, Myeongjin
Butcher, Rebecca A
Kim, Kyuhyung
Sengupta, Piali
author_sort Neal, Scott J
collection PubMed
description Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state. CMK-1 acts cell-autonomously in the ASI, and non cell-autonomously in the AWC, sensory neurons to regulate expression of the growth promoting daf-7 TGF-β and daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state regulates dynamic subcellular localization of CMK-1, and CMK-1-dependent expression of anti-dauer ILP genes, in AWC. A food-regulated balance between anti-dauer ILP signals from AWC and pro-dauer signals regulates neuroendocrine signaling and dauer entry; disruption of this balance in cmk-1 mutants drives inappropriate dauer formation under well-fed conditions. These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity. DOI: http://dx.doi.org/10.7554/eLife.10110.001
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spelling pubmed-45585642015-09-08 Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling Neal, Scott J Takeishi, Asuka O'Donnell, Michael P Park, JiSoo Hong, Myeongjin Butcher, Rebecca A Kim, Kyuhyung Sengupta, Piali eLife Developmental Biology and Stem Cells Information about nutrient availability is assessed via largely unknown mechanisms to drive developmental decisions, including the choice of Caenorhabditis elegans larvae to enter into the reproductive cycle or the dauer stage. In this study, we show that CMK-1 CaMKI regulates the dauer decision as a function of feeding state. CMK-1 acts cell-autonomously in the ASI, and non cell-autonomously in the AWC, sensory neurons to regulate expression of the growth promoting daf-7 TGF-β and daf-28 insulin-like peptide (ILP) genes, respectively. Feeding state regulates dynamic subcellular localization of CMK-1, and CMK-1-dependent expression of anti-dauer ILP genes, in AWC. A food-regulated balance between anti-dauer ILP signals from AWC and pro-dauer signals regulates neuroendocrine signaling and dauer entry; disruption of this balance in cmk-1 mutants drives inappropriate dauer formation under well-fed conditions. These results identify mechanisms by which nutrient information is integrated in a small neuronal network to modulate neuroendocrine signaling and developmental plasticity. DOI: http://dx.doi.org/10.7554/eLife.10110.001 eLife Sciences Publications, Ltd 2015-09-03 /pmc/articles/PMC4558564/ /pubmed/26335407 http://dx.doi.org/10.7554/eLife.10110 Text en © 2015, Neal et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology and Stem Cells
Neal, Scott J
Takeishi, Asuka
O'Donnell, Michael P
Park, JiSoo
Hong, Myeongjin
Butcher, Rebecca A
Kim, Kyuhyung
Sengupta, Piali
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title_full Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title_fullStr Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title_full_unstemmed Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title_short Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
title_sort feeding state-dependent regulation of developmental plasticity via camki and neuroendocrine signaling
topic Developmental Biology and Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558564/
https://www.ncbi.nlm.nih.gov/pubmed/26335407
http://dx.doi.org/10.7554/eLife.10110
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