Cargando…
Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance
Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients...
Autores principales: | , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558595/ https://www.ncbi.nlm.nih.gov/pubmed/26314987 http://dx.doi.org/10.1038/bcj.2015.71 |
_version_ | 1782388643834363904 |
---|---|
author | Piot, J M Royer, M Schmidt-Tanguy, A Hoppé, E Gardembas, M Bourrée, T Hunault, M François, S Boyer, F Ifrah, N Renier, G Chevailler, A Audran, M Chappard, D Libouban, H Mabilleau, G Legrand, E Bouvard, B |
author_facet | Piot, J M Royer, M Schmidt-Tanguy, A Hoppé, E Gardembas, M Bourrée, T Hunault, M François, S Boyer, F Ifrah, N Renier, G Chevailler, A Audran, M Chappard, D Libouban, H Mabilleau, G Legrand, E Bouvard, B |
author_sort | Piot, J M |
collection | PubMed |
description | Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients. All patients had spinal radiographs and bone mineral density measurement in addition to gammopathy assessment. At least one prevalent non-traumatic vertebral fracture was discovered in 18.4% patients and equally distributed between men and women. Fractured patients were older, had a lower bone density and had also more frequently a lambda light chain isotype. Compared with patients with κ light chain, the odds ratio of being fractured for patients with λ light chain was 4.32 (95% confidence interval 1.80–11.16; P=0.002). These results suggest a high prevalence of non-traumatic vertebral fractures in MGUS associated with lambda light chain isotype and not only explained by low bone density. |
format | Online Article Text |
id | pubmed-4558595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-45585952015-09-14 Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance Piot, J M Royer, M Schmidt-Tanguy, A Hoppé, E Gardembas, M Bourrée, T Hunault, M François, S Boyer, F Ifrah, N Renier, G Chevailler, A Audran, M Chappard, D Libouban, H Mabilleau, G Legrand, E Bouvard, B Blood Cancer J Original Article Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated with vertebral fracture. We included prospectively 201 patients with MGUS, incidentally discovered, and with no known history of osteoporosis: mean age 66.6±12.5 years, 48.3% women, 51.7% immunoglobulin G (IgG), 33.3% IgM and 10.4% IgA. Light chain was kappa in 64.2% patients. All patients had spinal radiographs and bone mineral density measurement in addition to gammopathy assessment. At least one prevalent non-traumatic vertebral fracture was discovered in 18.4% patients and equally distributed between men and women. Fractured patients were older, had a lower bone density and had also more frequently a lambda light chain isotype. Compared with patients with κ light chain, the odds ratio of being fractured for patients with λ light chain was 4.32 (95% confidence interval 1.80–11.16; P=0.002). These results suggest a high prevalence of non-traumatic vertebral fractures in MGUS associated with lambda light chain isotype and not only explained by low bone density. Nature Publishing Group 2015-08 2015-08-28 /pmc/articles/PMC4558595/ /pubmed/26314987 http://dx.doi.org/10.1038/bcj.2015.71 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Piot, J M Royer, M Schmidt-Tanguy, A Hoppé, E Gardembas, M Bourrée, T Hunault, M François, S Boyer, F Ifrah, N Renier, G Chevailler, A Audran, M Chappard, D Libouban, H Mabilleau, G Legrand, E Bouvard, B Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title | Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title_full | Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title_fullStr | Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title_full_unstemmed | Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title_short | Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
title_sort | factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558595/ https://www.ncbi.nlm.nih.gov/pubmed/26314987 http://dx.doi.org/10.1038/bcj.2015.71 |
work_keys_str_mv | AT piotjm factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT royerm factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT schmidttanguya factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT hoppee factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT gardembasm factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT bourreet factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT hunaultm factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT francoiss factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT boyerf factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT ifrahn factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT renierg factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT chevaillera factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT audranm factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT chappardd factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT liboubanh factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT mabilleaug factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT legrande factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance AT bouvardb factorsassociatedwithanincreasedriskofvertebralfractureinmonoclonalgammopathiesofundeterminedsignificance |