Cargando…

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β

Aberrant activation of Wnt/β-catenin signaling plays an unequivocal role in colorectal cancer, but identification of effective Wnt inhibitors for use in cancer remains a tremendous challenge. New insights into the regulation of this pathway could reveal new therapeutic point of intervention, therefo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Chenxi, Chen, Guangming, Kuan, Shih-Fan, Zhang, Dennis Han, Schlaepfer, David D, Hu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558782/ https://www.ncbi.nlm.nih.gov/pubmed/26274564 http://dx.doi.org/10.7554/eLife.10072

Ejemplares similares

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-Catenin(Y654)
por: Gao, Chenxi, et al.
Publicado: (2019)

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
por: van Veelen, Wendy, et al.
Publicado: (2011)

Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway
por: Bae, Sowon, et al.
Publicado: (2022)

Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6
por: Stamos, Jennifer L, et al.
Publicado: (2014)

Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method
por: Sun, Ying-Chieh
Publicado: (2009)

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling
por: Piao, Shunfu, et al.
Publicado: (2008)

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
por: Wu, Geng, et al.
Publicado: (2009)

Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair
por: Thomas, Keena S., et al.
Publicado: (2019)

Transcription factor EB (TFEB) improves ventricular remodeling after myocardial infarction by inhibiting Wnt/β-catenin signaling pathway
por: Liu, Cong, et al.
Publicado: (2023)

Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis
por: Alula, Kibrom M., et al.
Publicado: (2020)

β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
por: Maher, Meghan T., et al.
Publicado: (2010)

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK
por: Weis, Sara M., et al.
Publicado: (2008)

Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β
por: Rask, K, et al.
Publicado: (2003)

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway
por: Zhang, Ying, et al.
Publicado: (2020)

20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway
por: Lin, Kaili, et al.
Publicado: (2020)

MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK‐3β/β‐catenin signalling
por: Shi, Yangfeng, et al.
Publicado: (2021)

Regulation of Wnt/β-catenin signaling by posttranslational modifications
por: Gao, Chenxi, et al.
Publicado: (2014)

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus
por: Orellana, Ana Maria Marques, et al.
Publicado: (2015)

Farnesoid X receptor antagonizes Wnt/β-catenin signaling in colorectal tumorigenesis
por: Yu, Junhui, et al.
Publicado: (2020)

β-catenin in epithelial tumorigenesis
por: Lu, Tsai-Ling, et al.
Publicado: (2015)

Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
por: Naser, Rayan, et al.
Publicado: (2018)

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
por: Topol, Lilia, et al.
Publicado: (2003)

Phosphorylation of human CEACAM1-LF by PKA and GSK3β promotes its interaction with β-catenin
por: Hu, Weidong, et al.
Publicado: (2021)

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2016)

A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations
por: Buchert, Michael, et al.
Publicado: (2015)

Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention
por: McCubrey, J A, et al.
Publicado: (2014)

The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
por: Predes, Danilo, et al.
Publicado: (2022)

The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability
por: Benelli, Roberto, et al.
Publicado: (2010)

GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation
por: John, Jobin K., et al.
Publicado: (2012)

Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
por: Nguyen, Vu Hong Loan, et al.
Publicado: (2019)

Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway
por: Wang, Zuoyun, et al.
Publicado: (2020)

FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation
por: Murphy, James M., et al.
Publicado: (2019)

Wnt-GSK3β/β-Catenin Regulates the Differentiation of Dental Pulp Stem Cells into Bladder Smooth Muscle Cells
por: Jiang, Wenkai, et al.
Publicado: (2019)

Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway
por: Zhang, Qian-Qian, et al.
Publicado: (2014)

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
por: Ryzhakov, Grigory, et al.
Publicado: (2021)

Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization
por: García de Herreros, Antonio, et al.
Publicado: (2019)

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis
por: Peignon, Grégory, et al.
Publicado: (2011)

Author Correction: Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction
por: Miao, Lei, et al.
Publicado: (2022)

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway
por: Zhan, Ping, et al.
Publicado: (2017)

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
por: Gao, Chenxi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bjerta451v2r0pggjufds8tt9l