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Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

BACKGROUND: Protein aggregation and its pathological effects are the major cause of several neurodegenerative diseases. In Huntington’s disease an elongated stretch of polyglutamines within the protein Huntingtin leads to increased aggregation propensity. This induces cellular defects, culminating i...

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Detalles Bibliográficos
Autores principales:	Papsdorf, Katharina, Kaiser, Christoph J. O., Drazic, Adrian, Grötzinger, Stefan W., Haeßner, Carmen, Eisenreich, Wolfgang, Richter, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558792/ https://www.ncbi.nlm.nih.gov/pubmed/26335097 http://dx.doi.org/10.1186/s12864-015-1831-7

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