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Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo
BACKGROUND: Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS). It is widely accepted that inflammatory cells play major roles in the pathogenesis of MS, possibly through the use of serine protease granzyme B (GrB) secreted from th...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558826/ https://www.ncbi.nlm.nih.gov/pubmed/26337722 http://dx.doi.org/10.1186/s12974-015-0376-7 |